Th2A cells: The pathogenic players in allergic diseases.

Th2A 细胞 ： 过敏性疾病的致病因素。

• 影响指数: 8.786
• 发表时间: 2022
• 来源期刊: Front Immunol
• DOI: 10.3389/fimmu.2022.916778
• PMID: 36003397
• 文章类型: Journal Article
• 中科院分区: Q2
• 方向: 医学
• 作者列表: Huang Z,Chu M,Chen X,Wang Z,Jiang L,Ma Y,Wang Y,Huang Z,Chu M,Chen X,Wang Z,Jiang L,Ma Y,Wang Y,Huang Z,Chu M,Chen X,Wang Z,Jiang L,Ma Y,Wang Y

关键词: CD161; CRTH2; HPGDS; ST2; Th2A cells; allergen-specific Th2 cells; allergic disease; CD161; CRTH2; HPGDS; ST2; Th2A cells; allergen-specific Th2 cells; allergic disease; CD161; CRTH2; HPGDS; ST2; Th2A cells; allergen-specific Th2 cells; allergic disease

Mesh: Allergens; Dermatitis, Atopic; Eosinophilic Esophagitis; Food Hypersensitivity; Humans; Rhinitis, Allergic; Allergens; Dermatitis, Atopic; Eosinophilic Esophagitis; Food Hypersensitivity; Humans; Rhinitis, Allergic

Abstract

Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3+ CD4+ HPGDS+ CRTH2+ CD161high ST2high CD49dhigh CD27low play a crucial role in allergic diseases, such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), asthma, and eosinophilic esophagitis (EoE). In this review, we summarize the discovery, biomarkers, and biological properties of Th2A cells to gain new insights into the pathogenesis of allergic diseases.

摘要

2型辅助性T（Th2A）细胞是仅限于特应性个体的记忆Th2细胞的子集，它们包括所有的过敏原特异性Th2细胞。最近,许多研究表明,以CD3+CD4+HPGDS+CRTH2+CD161highST2highCD49dhighCD27low为特征的Th2A细胞在过敏性疾病中起着至关重要的作用,如特应性皮炎（AD），食物过敏(FA),过敏性鼻炎（AR），哮喘,和嗜酸性粒细胞性食管炎（EoE）。在这次审查中,我们总结了这一发现，生物标志物，Th2A细胞的生物学特性,从而对过敏性疾病的发病机制有新的认识。