PDF(Pubmed)
Abstract：
Fair inclusion of research subjects is necessary to ensure that post-acute sequelae COVID-19 (PASC) research results benefit all members of society. Scientists should conduct research on a broad sample of individuals who represent clinically relevant factors influencing a disease. Without demographic diversity and sociological and environmental variability, research outputs are less likely to apply to different populations and would thus increase health disparities. The goal of this narrative literature review and ethical analysis is to apply fair selection criteria to PASC research studies. We briefly highlight the importance of fair subject selection in translational research and then identify features of PASC, as well as PASC research, that hinder fair inclusion of research participants. We will demonstrate that determining an adequate and representative sample is not simply a matter of ensuring greater diversity; rather, fairness requires a broader evaluation of risks, burdens, and benefits specific to underrepresented populations. We provide recommendations to ensure fair subject selection in PASC research and promote translation toward positive health outcomes for all individuals, including the most vulnerable.
摘要：
公平纳入研究对象对于确保急性后遗症COVID-19（PASC）研究结果使社会所有成员受益是必要的。科学家应该对代表影响疾病的临床相关因素的广泛个体样本进行研究。没有人口的多样性和社会及环境的多变性,研究产出不太可能适用于不同的人群，因此会增加健康差距。本叙事文献综述和伦理分析的目的是将公平的选择标准应用于PASC研究。我们简要强调翻译研究中公平选择主题的重要性，然后确定PASC的特征，以及PASC的研究，这阻碍了研究参与者的公平包容。我们将证明，确定一个足够和有代表性的样本不仅仅是确保更大的多样性；公平需要对风险进行更广泛的评估，负担,以及代表性不足的人群特有的福利。我们提供建议，以确保在PASC研究中公平选择主题，并促进所有个人的积极健康结果。包括最脆弱的人。
