Abstract：
This review aimed to identify the influence of antimicrobial and cleaning agents on surface characteristics such as surface free energy (SFE) and wettability, and microbial adhesion in polymethylmethacrylate (PMMA) for denture base. The review question, based on PICO, was: \"Does intervention with antimicrobial and cleaning agents in PMMA influence the surface free energy, wettability, and consequently the microbial adhesion?\" and the protocol was registered in Open Science Framework (osf. io/v3xgn). The search was performed in PubMed, Lilacs, Embase, Scopus, and Science Direct databases, using the terms: (\"acrylic resin\" OR PMMA) AND (antimicrobial OR antibacterial) AND (\"electrostatic interaction\" OR surface free energy) AND (biofilm OR \"bacteria adhesion\"), and resulted in 462 articles, of which 7 were included. The antimicrobials polypara-xylylene, carboxybetaine methacrylate, ethylene glycol methacrylate phosphate, and deposition of F and Ag ions in PMMA influenced the SFE and wettability. Denture cleaners reduced microbial adhesion. Five of the included studies evaluated the microbial adhesion, however, only two observed a direct relationship between SFE, wettability, and microbial adhesion. It was concluded that the intervention with antimicrobial and cleaning agents in PMMA can interfere in SFE and surface wettability, but no correlation was observed between microbial adhesion and these surface characteristics in PMMA.
摘要：
这篇综述旨在确定抗菌剂和清洁剂对表面特性如表面自由能（SFE）和润湿性的影响，和微生物在聚甲基丙烯酸甲酯（PMMA）义齿基托中的粘附。审查问题，基于PICO,是：“PMMA中的抗菌剂和清洁剂的干预是否会影响表面自由能，润湿性,因此微生物粘附？“，该方案在开放科学框架(osf。io/v3xgn)。搜索是在PubMed中进行的，丁香花,Embase,Scopus,和科学直接数据库，使用以下术语：（\“丙烯酸树脂\”或PMMA）和（抗菌或抗菌）和（\“静电相互作用\”或表面自由能）和（生物膜或“细菌粘附”），产生了462篇文章，其中包括7个。抗菌剂聚对二甲苯，羧基甜菜碱甲基丙烯酸酯，乙二醇甲基丙烯酸酯磷酸酯，PMMA中F和Ag离子的沉积影响了SFE和润湿性。义齿清洁剂减少微生物粘附。纳入的五项研究评估了微生物粘附，然而,只有两个人观察到SFE之间有直接关系，润湿性,和微生物粘附。结论是，在PMMA中使用抗菌剂和清洁剂的干预可以干扰SFE和表面润湿性。但是在PMMA中没有观察到微生物粘附与这些表面特征之间的相关性。
