UNASSIGNED: After screening 138 cases of MCL, we identified eight cases of MCL with EBV infection.
UNASSIGNED: Most of them (7/8) had non-neoplastic bystander cells with positivity for EBV and no expression of latent membrane protein 1 (LMP1) and EBV nuclear antigen 2 (EBNA2). The cases of MCL with EBER positivity did not have abnormal immune function or other lymphomas. Moreover, their histopathological morphology was indicative of classical MCL. Cases of MCL with EBER positivity exhibited statistically significant differences in lactate dehydrogenase, anemia status, and MCL international prognostic index grouping (P=0.008, P=0.02, P=0.001, and P=0.011, respectively). The differences between the two groups in age, sex ratio, clinical manifestations, and immunohistochemical phenotypes were not statistically significant.
UNASSIGNED: The incidence of MCL with EBV infection was low (5.8%). Clinicopathologically, cases of MCL with EBER positivity were similar to their EBV-negative counterparts. Our findings revealed that most cells infected by EBV in MCL are background cells rather than tumor cells. This is inconsistent with data from previous studies, indicating that tumor cells in MCL may not be prone to EBV infection.
■在筛查了138例MCL后,我们发现8例MCL合并EBV感染。
■其中大多数(7/8)具有对EBV阳性的非肿瘤旁观者细胞,并且不表达潜伏膜蛋白1(LMP1)和EBV核抗原2(EBNA2)。EBER阳性的MCL病例没有免疫功能异常或其他淋巴瘤。此外,它们的组织病理学形态表明是经典MCL。EBER阳性的MCL病例在乳酸脱氢酶方面表现出统计学上的显着差异,贫血状态,和MCL国际预后指数分组(分别为P=0.008,P=0.02,P=0.001和P=0.011)。两组在年龄上的差异,性别比例,临床表现,和免疫组织化学表型无统计学意义。
■MCL合并EBV感染的发生率较低(5.8%)。临床病理,EBER阳性的MCL病例与其EBV阴性的病例相似。我们的发现表明,MCL中被EBV感染的大多数细胞是背景细胞而不是肿瘤细胞。这与以前的研究数据不一致,表明MCL中的肿瘤细胞可能不容易感染EBV。