PDF(Pubmed)
Abstract：
Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin\'s lymphoma (NHL). This subtype can be present in various extranodal sites, including the brain, bones, intestines, kidneys, adrenal glands, and other soft tissues. As demonstrated in this case, one rare site of DLBCL is the nasal septum, which presents as a rapidly enlarging mass resistant to antibiotics and steroids. The definitive diagnosis for this case involved biopsy, but further workup, such as computed tomography (CT) and fluorescence in situ hybridization (FISH), helped support the diagnosis of DLBCL. While determining the stage of the lymphoma, treatment with R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) was initiated immediately. This case demonstrates a rare presentation of DLBCL in the nasal septum and describes the significance of urgent examination as well as treatment.
摘要：
弥漫性大B细胞淋巴瘤(DLBCL)是非霍奇金淋巴瘤(NHL)最常见的亚型。这种亚型可以存在于各种结外位点，包括大脑,骨头,肠子,肾脏，肾上腺,和其他软组织。正如在这种情况下所证明的，DLBCL的一个罕见部位是鼻中隔，表现为对抗生素和类固醇具有抗性的快速扩大的质量。这个病例的明确诊断包括活检,但是进一步的工作，如计算机断层扫描（CT）和荧光原位杂交（FISH），帮助支持DLBCL的诊断。在确定淋巴瘤的分期时，用R-CHOP化疗治疗（利妥昔单抗，环磷酰胺,阿霉素,长春新碱,和泼尼松）立即开始。此病例显示鼻中隔中DLBCL的罕见表现，并描述了紧急检查和治疗的意义。
