PDF(Pubmed)
Abstract：
BACKGROUND: Patients with β-thalassemia major (β-TM), a genetic issue due to hemoglobin (Hb) synthesis disorder, require life-long erythrocyte transfusion. The purpose of this study is to evaluate and compare gingival pigmentation and skin color with serum ferritin levels of patients with β-TM, using the Dummett\'s oral pigmentation index (DOPI) and Fitzpatrick skin scale, respectively.
METHODS: A total of 100 patients were monitored at a thalassemia care center. Each patient\'s gingival pigmentation and skin color were matched with DOPI and the skin scale under natural light. Serum ferritin levels, the interval of blood transfusions, and iron chelation medications were studied. A gingival pigmentation score and skin color type were compared with the serum ferritin.
RESULTS: A significant correlation was found between age, serum ferritin, pigmentation score, and skin color, which means as serum ferritin level increases, gingival pigmentation score increases, and skin color darkens.
CONCLUSIONS: This study evaluated the correlation between gingival pigmentation and skin color with serum ferritin levels and established gingival pigmentation as a sign of iron deposition in β-TM patients. This is the simplest and least invasive method for evaluating serum ferritin level parameters in β-TM patients.
METHODS: A total of 100 patients were monitored at a thalassemia care center. Each patient\'s gingival pigmentation and skin color were matched with DOPI and the skin scale under natural light. Serum ferritin levels, the interval of blood transfusions, and iron chelation medications were studied. A gingival pigmentation score and skin color type were compared with the serum ferritin.
RESULTS: A significant correlation was found between age, serum ferritin, pigmentation score, and skin color, which means as serum ferritin level increases, gingival pigmentation score increases, and skin color darkens.
CONCLUSIONS: This study evaluated the correlation between gingival pigmentation and skin color with serum ferritin levels and established gingival pigmentation as a sign of iron deposition in β-TM patients. This is the simplest and least invasive method for evaluating serum ferritin level parameters in β-TM patients.
摘要：
背景：重型β-地中海贫血（β-TM）患者，由血红蛋白（Hb）合成障碍引起的遗传问题，需要终身输注红细胞。本研究的目的是评估和比较β-TM患者的牙龈色素沉着和皮肤颜色与血清铁蛋白水平。使用Dummett口腔色素沉着指数（DOPI）和Fitzpatrick皮肤量表，分别。
方法：共有100名患者在地中海贫血护理中心接受监测。每个患者的牙龈色素沉着和皮肤颜色与DOPI和自然光下的皮肤量表相匹配。血清铁蛋白水平,输血的间隔，和铁螯合药物进行了研究。将牙龈色素沉着评分和皮肤颜色类型与血清铁蛋白进行比较。
结果：发现年龄之间存在显着相关性，血清铁蛋白,色素沉着评分,和肤色，这意味着随着血清铁蛋白水平的增加，牙龈色素沉着评分增加，肤色变暗。
结论：这项研究评估了牙龈色素沉着和皮肤颜色与血清铁蛋白水平之间的相关性，并确定了牙龈色素沉着是β-TM患者铁沉积的标志。这是评估β-TM患者血清铁蛋白水平参数的最简单且侵入性最小的方法。
方法：共有100名患者在地中海贫血护理中心接受监测。每个患者的牙龈色素沉着和皮肤颜色与DOPI和自然光下的皮肤量表相匹配。血清铁蛋白水平,输血的间隔，和铁螯合药物进行了研究。将牙龈色素沉着评分和皮肤颜色类型与血清铁蛋白进行比较。
结果：发现年龄之间存在显着相关性，血清铁蛋白,色素沉着评分,和肤色，这意味着随着血清铁蛋白水平的增加，牙龈色素沉着评分增加，肤色变暗。
结论：这项研究评估了牙龈色素沉着和皮肤颜色与血清铁蛋白水平之间的相关性，并确定了牙龈色素沉着是β-TM患者铁沉积的标志。这是评估β-TM患者血清铁蛋白水平参数的最简单且侵入性最小的方法。
