Co-occurrence of CML Blast Crisis and Severe COVID 19 Infection: A Case Report.

慢性粒细胞白血病爆发危机与严重 COVID 19 感染并存 1 例.

• 发表时间: Jul 2022
• 来源期刊: Cureus
• DOI: 10.7759/cureus.26865
• PMID: 35989789
• 文章类型: Case Reports
• 作者列表: Khaja M,Hayagreev V,Haider A,Ronderos D,Siddiqa A,Moirangthem V,Khaja M,Hayagreev V,Haider A,Ronderos D,Siddiqa A,Moirangthem V

关键词: blast crisis; chronic myeloid leukemia (cml); corona virus disease 2019; imatinib therapy; invasive mechanical ventilation; blast crisis; chronic myeloid leukemia (cml); corona virus disease 2019; imatinib therapy; invasive mechanical ventilation

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affecting multiple organ systems. It can cause severe cytokine storms leading to intensive care unit admission requiring mechanical ventilation. However, there have been few studies establishing the outcomes of chronic myeloid leukemia (CML) patients on tyrosine kinase inhibitors who are infected with COVID-19. We present a 69-year-old male with a history of CML on imatinib therapy with COVID-19 who developed acute respiratory distress syndrome needing mechanical ventilatory support, shock requiring vasopressors, and worse outcome secondary to blast crisis.

摘要

2019年冠状病毒病（COVID-19）是由严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）引起的，影响多器官系统。它会导致严重的细胞因子风暴，导致重症监护病房入院需要机械通气。然而,很少有研究确定感染COVID-19的慢性髓性白血病(CML)患者接受酪氨酸激酶抑制剂治疗的结局.我们介绍了一名69岁的男性，有CML病史，在伊马替尼治疗COVID-19，他出现了急性呼吸窘迫综合征，需要机械通气支持，需要血管加压药的休克,更糟糕的结果仅次于爆炸危机。