METHODS: We designed the current study to appraise dysregulation of nine oxytocin-associated mRNAs and lncRNAs in the venous blood of patients with schizophrenia.
RESULTS: Expression of FOS was up-regulated in total patients compared with total control group (Expression ratio (95% CI)= 13.64 (5.46-34.05), adjusted P value<0.0001) and in female patients compared with female control group (Expression ratio (95% CI)=32.13 (5.81-176), adjusted P value<0.0001). Such pattern was also seen for Lnc-FOXF1 (Expression ratio (95% CI)= 6.41 (2.84-14.3), adjusted P value<0.0001 and Expression ratio (95% CI)= 14.41 (3.2-64.44), adjusted P value<0.0001, respectively). ITPR1 was down-regulated in total patients compared with total controls (Expression ratio (95% CI)= 0.22 (0.076-0.67), adjusted P value=0.0079). ROC curve analyses demonstrated that FOS had the best AUC value among other genes in differentiation between patients and controls (AUC=0.78).
CONCLUSIONS: The above-mentioned results imply dysregulation of oxytocin-related genes in the circulatory blood of patients with schizophrenia.
方法:我们设计了本研究来评估精神分裂症患者静脉血中9种催产素相关mRNA和lncRNA的失调。
结果:与总对照组相比,总患者中FOS的表达上调(表达比(95%CI)=13.64(5.46-34.05),调整后的P值<0.0001),女性患者与女性对照组相比(表达比(95%CI)=32.13(5.81-176),调整后的P值<0.0001)。Lnc-FOXF1也观察到了这种模式(表达比(95%CI)=6.41(2.84-14.3),调整后的P值<0.0001,表达式比率(95%CI)=14.41(3.2-64.44),调整后的P值分别<0.0001)。与总对照相比,ITPR1在总患者中下调(表达比(95%CI)=0.22(0.076-0.67),调整后的P值=0.0079)。ROC曲线分析表明,在患者和对照组之间的分化中,FOS在其他基因中具有最佳的AUC值(AUC=0.78)。
结论:上述结果提示精神分裂症患者循环血液中催产素相关基因失调。