Abstract：
BACKGROUND: Schizophrenia is a neuropsychiatric disorder characterized by a variety of clinical manifestations. This disorder has a complex inheritance. Oxytocinegic system has been shown to be implicated in the pathophysiology of schizophrenia. This system can alter social cognition through direct interaction with dopaminergic signaling, facilitating brain-stimulation reward, reduction of defense mechanism and stress reactivity, and modulation of social information processing through enhancing the greatness of social incentives. Long non-coding RNAs (lncRNAs) can affect activity of oxytocinegic system, thus contributing in the etiology of this disorder.
METHODS: We designed the current study to appraise dysregulation of nine oxytocin-associated mRNAs and lncRNAs in the venous blood of patients with schizophrenia.
RESULTS: Expression of FOS was up-regulated in total patients compared with total control group (Expression ratio (95% CI)= 13.64 (5.46-34.05), adjusted P value<0.0001) and in female patients compared with female control group (Expression ratio (95% CI)=32.13 (5.81-176), adjusted P value<0.0001). Such pattern was also seen for Lnc-FOXF1 (Expression ratio (95% CI)= 6.41 (2.84-14.3), adjusted P value<0.0001 and Expression ratio (95% CI)= 14.41 (3.2-64.44), adjusted P value<0.0001, respectively). ITPR1 was down-regulated in total patients compared with total controls (Expression ratio (95% CI)= 0.22 (0.076-0.67), adjusted P value=0.0079). ROC curve analyses demonstrated that FOS had the best AUC value among other genes in differentiation between patients and controls (AUC=0.78).
CONCLUSIONS: The above-mentioned results imply dysregulation of oxytocin-related genes in the circulatory blood of patients with schizophrenia.
METHODS: We designed the current study to appraise dysregulation of nine oxytocin-associated mRNAs and lncRNAs in the venous blood of patients with schizophrenia.
RESULTS: Expression of FOS was up-regulated in total patients compared with total control group (Expression ratio (95% CI)= 13.64 (5.46-34.05), adjusted P value<0.0001) and in female patients compared with female control group (Expression ratio (95% CI)=32.13 (5.81-176), adjusted P value<0.0001). Such pattern was also seen for Lnc-FOXF1 (Expression ratio (95% CI)= 6.41 (2.84-14.3), adjusted P value<0.0001 and Expression ratio (95% CI)= 14.41 (3.2-64.44), adjusted P value<0.0001, respectively). ITPR1 was down-regulated in total patients compared with total controls (Expression ratio (95% CI)= 0.22 (0.076-0.67), adjusted P value=0.0079). ROC curve analyses demonstrated that FOS had the best AUC value among other genes in differentiation between patients and controls (AUC=0.78).
CONCLUSIONS: The above-mentioned results imply dysregulation of oxytocin-related genes in the circulatory blood of patients with schizophrenia.
摘要：
背景：精神分裂症是一种以多种临床表现为特征的神经精神障碍。这种疾病具有复杂的遗传。已证明催产能系统与精神分裂症的病理生理学有关。该系统可以通过与多巴胺能信号的直接相互作用来改变社会认知，促进大脑刺激奖励，防御机制和应激反应性的降低，通过增强社会激励的伟大性来调节社会信息处理。长链非编码RNA（lncRNAs）可以影响催产系统的活性，从而有助于这种疾病的病因。
方法：我们设计了本研究来评估精神分裂症患者静脉血中9种催产素相关mRNA和lncRNA的失调。
结果：与总对照组相比，总患者中FOS的表达上调（表达比（95％CI）=13.64（5.46-34.05），调整后的P值<0.0001），女性患者与女性对照组相比（表达比（95％CI）=32.13（5.81-176），调整后的P值<0.0001)。Lnc-FOXF1也观察到了这种模式(表达比(95%CI)=6.41(2.84-14.3)，调整后的P值<0.0001，表达式比率（95%CI）=14.41（3.2-64.44），调整后的P值分别<0.0001)。与总对照相比，ITPR1在总患者中下调（表达比（95％CI）=0.22（0.076-0.67），调整后的P值=0.0079)。ROC曲线分析表明，在患者和对照组之间的分化中，FOS在其他基因中具有最佳的AUC值（AUC=0.78）。
结论：上述结果提示精神分裂症患者循环血液中催产素相关基因失调。
方法：我们设计了本研究来评估精神分裂症患者静脉血中9种催产素相关mRNA和lncRNA的失调。
结果：与总对照组相比，总患者中FOS的表达上调（表达比（95％CI）=13.64（5.46-34.05），调整后的P值<0.0001），女性患者与女性对照组相比（表达比（95％CI）=32.13（5.81-176），调整后的P值<0.0001)。Lnc-FOXF1也观察到了这种模式(表达比(95%CI)=6.41(2.84-14.3)，调整后的P值<0.0001，表达式比率（95%CI）=14.41（3.2-64.44），调整后的P值分别<0.0001)。与总对照相比，ITPR1在总患者中下调（表达比（95％CI）=0.22（0.076-0.67），调整后的P值=0.0079)。ROC曲线分析表明，在患者和对照组之间的分化中，FOS在其他基因中具有最佳的AUC值（AUC=0.78）。
结论：上述结果提示精神分裂症患者循环血液中催产素相关基因失调。
