PDF(Pubmed)
Abstract：
Acute kidney injury (AKI) is a frequently encountered syndrome especially among the critically ill. Current diagnosis of AKI is based on acute deterioration of kidney function, indicated by an increase in creatinine and/or reduced urine output. However, this syndromic definition encompasses a wide variety of distinct clinical features, varying pathophysiology, etiology and risk factors, and finally very different short- and long-term outcomes. Lumping all AKI together may conceal unique pathophysiologic processes specific to certain AKI populations, and discovering these AKI subphenotypes might help to develop targeted therapies tackling unique pathophysiological processes. In this review, we discuss the concept of AKI subphenotypes, current knowledge regarding both clinical and biomarker-driven subphenotypes, interplay with AKI subphenotypes and other ICU syndromes, and potential future and clinical implications.
摘要：
急性肾损伤（AKI）是一种经常遇到的综合征，尤其是在重症患者中。目前AKI的诊断是基于肾功能的急性恶化，肌酐增加和/或尿量减少。然而,这个综合征的定义包括各种各样的不同的临床特征，不同的病理生理学，病因和危险因素，最后是非常不同的短期和长期结果。将所有AKI集中在一起可能会隐藏某些AKI人群特有的独特病理生理过程。发现这些AKI亚型可能有助于开发针对独特病理生理过程的靶向疗法。在这次审查中,我们讨论了AKI亚型的概念，关于临床和生物标志物驱动的亚表型的最新知识，与AKI亚型和其他ICU综合征相互作用，以及潜在的未来和临床意义。
