Abstract：
OBJECTIVE: We sought to determine whether acute delta 9-tetrahyrdrocannabidol (THC) administration would facilitate fear extinction in young occasional cannabis users, given that animal models indicate THC facilitates extinction learning, and recent studies indicate THC administration may also enhance threat memory extinction in humans.
METHODS: On each of the 2 days, 24+ hour THC-deprived participants were conditioned to fear visual stimuli in a delay conditioning and extinction paradigm. Both CS+ and CS- were faces of negative emotional valence, with the CS+ paired with mild electric shock. Throughout both conditioning and extinction paradigms, EEG was measured to quantify event-related potentials for these learning processes. Following conditioning, individuals, in a randomized and counter-balanced order, smoked either an active THC cigarette (26.25 mg/2.7% THC) or a placebo marijuana cigarette (0.002% THC) on 1 day and the opposite cigarette on the second day. After smoking, CS+ and CS- were presented without shock, resulting in extinction of conditioned fear.
RESULTS: Relative to placebo, THC facilitated extinction of the conditioned response to the CS+, as reflected by reductions in late positive potential amplitude during extinction learning.
CONCLUSIONS: The results indicate that acute THC administration may facilitate extinction of the conditioned fear response in humans.
METHODS: On each of the 2 days, 24+ hour THC-deprived participants were conditioned to fear visual stimuli in a delay conditioning and extinction paradigm. Both CS+ and CS- were faces of negative emotional valence, with the CS+ paired with mild electric shock. Throughout both conditioning and extinction paradigms, EEG was measured to quantify event-related potentials for these learning processes. Following conditioning, individuals, in a randomized and counter-balanced order, smoked either an active THC cigarette (26.25 mg/2.7% THC) or a placebo marijuana cigarette (0.002% THC) on 1 day and the opposite cigarette on the second day. After smoking, CS+ and CS- were presented without shock, resulting in extinction of conditioned fear.
RESULTS: Relative to placebo, THC facilitated extinction of the conditioned response to the CS+, as reflected by reductions in late positive potential amplitude during extinction learning.
CONCLUSIONS: The results indicate that acute THC administration may facilitate extinction of the conditioned fear response in humans.
摘要：
目的：我们试图确定急性δ9-四氢大麻酚（THC）的使用是否会促进偶尔使用大麻的年轻人的恐惧灭绝，鉴于动物模型表明THC有助于灭绝学习，最近的研究表明，THC的管理也可能增加威胁记忆灭绝的人类。
方法：在每两天，24小时THC剥夺的参与者在延迟条件和灭绝范式中受到恐惧的视觉刺激。CS+和CS-都是负面情绪效价的面孔，与CS+搭配轻度电击。在调节和灭绝范式中，测量EEG以量化这些学习过程的事件相关电位。调节后,个人,以随机和平衡的顺序，第1天抽活性THC香烟（26.25mg/2.7％THC）或安慰剂大麻香烟（0.002％THC），第2天抽相反的香烟。吸烟后，CS+和CS-出现时没有休克，导致条件恐惧的灭绝。
结果：相对于安慰剂，THC促进了对CS的条件响应的灭绝，这反映在灭绝学习过程中晚期正电位振幅的减少。
结论：结果表明，急性THC给药可能促进人类条件性恐惧反应的消退。
方法：在每两天，24小时THC剥夺的参与者在延迟条件和灭绝范式中受到恐惧的视觉刺激。CS+和CS-都是负面情绪效价的面孔，与CS+搭配轻度电击。在调节和灭绝范式中，测量EEG以量化这些学习过程的事件相关电位。调节后,个人,以随机和平衡的顺序，第1天抽活性THC香烟（26.25mg/2.7％THC）或安慰剂大麻香烟（0.002％THC），第2天抽相反的香烟。吸烟后，CS+和CS-出现时没有休克，导致条件恐惧的灭绝。
结果：相对于安慰剂，THC促进了对CS的条件响应的灭绝，这反映在灭绝学习过程中晚期正电位振幅的减少。
结论：结果表明，急性THC给药可能促进人类条件性恐惧反应的消退。
