METHODS: On each of the 2 days, 24+ hour THC-deprived participants were conditioned to fear visual stimuli in a delay conditioning and extinction paradigm. Both CS+ and CS- were faces of negative emotional valence, with the CS+ paired with mild electric shock. Throughout both conditioning and extinction paradigms, EEG was measured to quantify event-related potentials for these learning processes. Following conditioning, individuals, in a randomized and counter-balanced order, smoked either an active THC cigarette (26.25 mg/2.7% THC) or a placebo marijuana cigarette (0.002% THC) on 1 day and the opposite cigarette on the second day. After smoking, CS+ and CS- were presented without shock, resulting in extinction of conditioned fear.
RESULTS: Relative to placebo, THC facilitated extinction of the conditioned response to the CS+, as reflected by reductions in late positive potential amplitude during extinction learning.
CONCLUSIONS: The results indicate that acute THC administration may facilitate extinction of the conditioned fear response in humans.
方法:在每两天,24小时THC剥夺的参与者在延迟条件和灭绝范式中受到恐惧的视觉刺激。CS+和CS-都是负面情绪效价的面孔,与CS+搭配轻度电击。在调节和灭绝范式中,测量EEG以量化这些学习过程的事件相关电位。调节后,个人,以随机和平衡的顺序,第1天抽活性THC香烟(26.25mg/2.7%THC)或安慰剂大麻香烟(0.002%THC),第2天抽相反的香烟。吸烟后,CS+和CS-出现时没有休克,导致条件恐惧的灭绝。
结果:相对于安慰剂,THC促进了对CS的条件响应的灭绝,这反映在灭绝学习过程中晚期正电位振幅的减少。
结论:结果表明,急性THC给药可能促进人类条件性恐惧反应的消退。