PDF(Pubmed)
Abstract：
UNASSIGNED: Acrokeratosis paraneoplastica of Bazex (APB) is a rare paraneoplastic dermatosis having definite association with malignancy, most commonly squamous cell carcinomas (SCC) of the upper aerodigestive tract. It is characterized by psoriasiform plaques involving the ears, nose, hands, and feet. Nail changes are commonly encountered, including onychauxis, subungual hyperkeratosis, xanthonychia, onycholysis, and onychorrhexis.
UNASSIGNED: We report the details of a 40-year-old male who presented with cutaneous changes involving both ears, palms, and soles and multiple nails, suggestive of APB. These typical changes were succeeded by an SCC of the lip.
UNASSIGNED: In 70% cases of APB, nail changes precede the diagnosis of the underlying neoplasm by up to 10 months, offering a good lead-time for early suspicion of malignancy. Our case highlights the importance of recognizing these changes early. An atypical location of malignancy (lower lip) and rare presentations, including painful acrokeratosis, melanonychia striata, and chloronychia, as seen in our case, should also be kept in mind.
UNASSIGNED: We report the details of a 40-year-old male who presented with cutaneous changes involving both ears, palms, and soles and multiple nails, suggestive of APB. These typical changes were succeeded by an SCC of the lip.
UNASSIGNED: In 70% cases of APB, nail changes precede the diagnosis of the underlying neoplasm by up to 10 months, offering a good lead-time for early suspicion of malignancy. Our case highlights the importance of recognizing these changes early. An atypical location of malignancy (lower lip) and rare presentations, including painful acrokeratosis, melanonychia striata, and chloronychia, as seen in our case, should also be kept in mind.
摘要：
■Bazex副原发肢端角化病（APB）是一种罕见的副肿瘤性皮肤病，与恶性肿瘤有明确的联系，最常见的上消化道鳞状细胞癌（SCC）。它的特征是涉及耳朵的银屑病样斑块，鼻子,手,和脚。通常会遇到指甲变化，包括甲癣,甲下角化过度,黄甲,甲状腺溶解症,和onychorrhexis。
■我们报道了一名40岁男性的细节，他表现出双耳的皮肤变化，手掌,鞋底和多个指甲，暗示着APB。这些典型的变化是由嘴唇的SCC成功的。
■在70%的APB病例中，指甲改变在诊断潜在肿瘤之前长达10个月，为早期怀疑恶性肿瘤提供了良好的准备时间。我们的案例强调了及早认识到这些变化的重要性。恶性肿瘤的非典型位置（下唇）和罕见的表现，包括疼痛的肢端角化病,黑甲癣,和绿甲,从我们的案例中可以看出，也应该记住。
■我们报道了一名40岁男性的细节，他表现出双耳的皮肤变化，手掌,鞋底和多个指甲，暗示着APB。这些典型的变化是由嘴唇的SCC成功的。
■在70%的APB病例中，指甲改变在诊断潜在肿瘤之前长达10个月，为早期怀疑恶性肿瘤提供了良好的准备时间。我们的案例强调了及早认识到这些变化的重要性。恶性肿瘤的非典型位置（下唇）和罕见的表现，包括疼痛的肢端角化病,黑甲癣,和绿甲,从我们的案例中可以看出，也应该记住。
