PDF(Pubmed)
Abstract：
The zoonotic H7N9 avian influenza virus emerged with the H9N2-origin internal gene cassette. Previous studies have reported that genetic reassortments with H9N2 were common in the first five human H7N9 epidemic waves. However, our latest work found that the circulating high pathogenicity H7N9 virus has established a dominant internal gene cassette and has decreased the frequency of reassortment with H9N2 since 2018. This dominant cassette of H7N9 was distinct from the cocirculating H9N2, although they shared a common ancestor. As a result, we suppose that this dominant cassette may benefit the viral population fitness and promote its continuous circulation in chickens.
摘要：
人畜共患H7N9禽流感病毒与H9N2来源的内部基因盒一起出现。先前的研究报告说，H9N2的基因重组在前五次人类H7N9流行波中很常见。然而,我们的最新工作发现,自2018年以来,循环的高致病性H7N9病毒已建立了显性内部基因盒,并降低了与H9N2的重配频率.尽管H7N9的优势盒与共同循环的H9N2不同，但它们具有共同的祖先。因此,我们认为这种优势盒可能有利于病毒种群的健康，并促进其在鸡中的持续循环。
