Abstract：
This study aimed to examine reclassification rates among classes of chronic obstructive pulmonary disease (COPD) patients based on their distinct symptom experiences and to assess how these subgroups differed in symptom scores and health-related quality of life (HRQoL) outcomes over one year. Moreover, we wished to assess how these subgroups differed in demographic and clinical characteristics at 12 months.
This is a follow-up study of 267 patients with moderate, severe, and very severe COPD. Based on their distinct symptom experiences using the Memorial Symptom Assessment Scale (MSAS), three subgroups (i.e., \"high\", \"intermediate\", and \"low\") were identified at baseline. In the present study, transitions between the subgroups at three, six, nine, and 12 months were investigated and calculated as reclassification rates. Differences among the subgroups in symptom scores and HRQoL at each time point and demographic and clinical characteristics at 12 months were evaluated using analysis of variance with post hoc comparisons.
Almost 65% were still in the \"high\" class after 12 months. At 12 months, pairwise comparisons for respiratory function measurements were not significantly different. Compared to the \"intermediate\" and \"low\" class, patients in the \"high\" class were more likely to be women and had significantly more comorbidities, reported a significantly higher number of symptoms at all time points, and worse HRQoL scores.
Our findings suggest that the pattern of a high symptom burden in COPD is consistent over time. The patients\' individual symptom experiences should be the primary focus of treatment.
This is a follow-up study of 267 patients with moderate, severe, and very severe COPD. Based on their distinct symptom experiences using the Memorial Symptom Assessment Scale (MSAS), three subgroups (i.e., \"high\", \"intermediate\", and \"low\") were identified at baseline. In the present study, transitions between the subgroups at three, six, nine, and 12 months were investigated and calculated as reclassification rates. Differences among the subgroups in symptom scores and HRQoL at each time point and demographic and clinical characteristics at 12 months were evaluated using analysis of variance with post hoc comparisons.
Almost 65% were still in the \"high\" class after 12 months. At 12 months, pairwise comparisons for respiratory function measurements were not significantly different. Compared to the \"intermediate\" and \"low\" class, patients in the \"high\" class were more likely to be women and had significantly more comorbidities, reported a significantly higher number of symptoms at all time points, and worse HRQoL scores.
Our findings suggest that the pattern of a high symptom burden in COPD is consistent over time. The patients\' individual symptom experiences should be the primary focus of treatment.
摘要：
这项研究旨在根据不同的症状经历检查慢性阻塞性肺疾病（COPD）患者类别的重新分类率，并评估这些亚组在症状评分和与健康相关的生活质量（HRQoL）结果在一年内的差异。此外，我们希望评估这些亚组在12个月时的人口统计学和临床特征有何不同.
这是一项对267名中度患者的随访研究，严重,非常严重的COPD。根据他们不同的症状经历，使用纪念症状评估量表(MSAS)，三个子组(即，\"高\",\"中间\",和“低”)在基线时被识别。在本研究中,三个子组之间的过渡，六,九,对12个月和12个月进行调查并计算为再分类率。使用方差分析和事后比较评估了每个时间点的症状评分和HRQoL以及12个月时的人口统计学和临床特征的亚组之间的差异。
近65%在12个月后仍处于“高”级别。12个月时,呼吸功能测量的成对比较没有显着差异。与“中间”和“低”类相比，“高级”类的患者更有可能是女性，并且合并症明显更多，报告的所有时间点的症状数量都显着增加，HRQoL得分更差。
我们的研究结果表明，随着时间的推移，COPD患者的高症状负担模式是一致的。患者的个体症状经历应该是治疗的主要重点。
这是一项对267名中度患者的随访研究，严重,非常严重的COPD。根据他们不同的症状经历，使用纪念症状评估量表(MSAS)，三个子组(即，\"高\",\"中间\",和“低”)在基线时被识别。在本研究中,三个子组之间的过渡，六,九,对12个月和12个月进行调查并计算为再分类率。使用方差分析和事后比较评估了每个时间点的症状评分和HRQoL以及12个月时的人口统计学和临床特征的亚组之间的差异。
近65%在12个月后仍处于“高”级别。12个月时,呼吸功能测量的成对比较没有显着差异。与“中间”和“低”类相比，“高级”类的患者更有可能是女性，并且合并症明显更多，报告的所有时间点的症状数量都显着增加，HRQoL得分更差。
我们的研究结果表明，随着时间的推移，COPD患者的高症状负担模式是一致的。患者的个体症状经历应该是治疗的主要重点。
