PDF(Pubmed)
Abstract：
Healthy aging relies on mitochondrial functioning because this organelle provides energy and diminishes oxidative stress. Single nucleotide polymorphisms (SNPs) in TOMM40, a critical gene that produces the outer membrane protein TOM40 of mitochondria, have been associated with mitochondrial dysfunction and neurodegenerative processes. Yet it is not clear whether or how the mitochondria may impact human longevity. We conducted this review to ascertain which SNPs have been associated with markers of healthy aging.
Using the PRISMA methodology, we conducted a systematic review on PubMed and Embase databases to identify associations between TOMM40 SNPs and measures of longevity and healthy aging.
Twenty-four articles were selected. The TOMM40 SNPs rs2075650 and rs10524523 were the two most commonly identified and studied SNPs associated with longevity. The outcomes associated with the TOMM40 SNPs were changes in BMI, brain integrity, cognitive functions, altered inflammatory network, vulnerability to vascular risk factors, and longevity.
Our systematic review identified multiple TOMM40 SNPs potentially associated with healthy aging. Additional research can help to understand mechanisms in aging, including resilience, prevention of disease, and adaptation to the environment.
Using the PRISMA methodology, we conducted a systematic review on PubMed and Embase databases to identify associations between TOMM40 SNPs and measures of longevity and healthy aging.
Twenty-four articles were selected. The TOMM40 SNPs rs2075650 and rs10524523 were the two most commonly identified and studied SNPs associated with longevity. The outcomes associated with the TOMM40 SNPs were changes in BMI, brain integrity, cognitive functions, altered inflammatory network, vulnerability to vascular risk factors, and longevity.
Our systematic review identified multiple TOMM40 SNPs potentially associated with healthy aging. Additional research can help to understand mechanisms in aging, including resilience, prevention of disease, and adaptation to the environment.
摘要：
健康衰老依赖于线粒体功能，因为这种细胞器提供能量并减少氧化应激。TOMM40中的单核苷酸多态性（SNPs）是产生线粒体外膜蛋白TOM40的关键基因，与线粒体功能障碍和神经退行性过程有关。然而，目前尚不清楚线粒体是否或如何影响人类的寿命。我们进行了这篇综述，以确定哪些SNP与健康衰老的标志物相关。
使用PRISMA方法，我们对PubMed和Embase数据库进行了系统评价,以确定TOMM40SNP与长寿和健康衰老指标之间的关联.
选择了24篇文章。TOMM40SNPsrs2075650和rs10524523是两个最常鉴定和研究的与长寿相关的SNP。与TOMM40SNP相关的结果是BMI的变化，大脑完整性,认知功能，炎症网络改变，对血管危险因素的脆弱性，和长寿。
我们的系统评价确定了多个可能与健康衰老相关的TOMM40SNP。额外的研究可以帮助理解衰老的机制，包括韧性，预防疾病,和适应环境。
使用PRISMA方法，我们对PubMed和Embase数据库进行了系统评价,以确定TOMM40SNP与长寿和健康衰老指标之间的关联.
选择了24篇文章。TOMM40SNPsrs2075650和rs10524523是两个最常鉴定和研究的与长寿相关的SNP。与TOMM40SNP相关的结果是BMI的变化，大脑完整性,认知功能，炎症网络改变，对血管危险因素的脆弱性，和长寿。
我们的系统评价确定了多个可能与健康衰老相关的TOMM40SNP。额外的研究可以帮助理解衰老的机制，包括韧性，预防疾病,和适应环境。
