Abstract：
BACKGROUND: Phenazopyridine is an azo dye, which exerts local anesthetic or analgesic action on urinary tract mucosa through an unknown mechanism. Besides its common complications including orange discoloration of the urine and gastrointestinal problems, it may have rare side effects like hemolytic anaemia, methemoglobinemia, renal failure, and skin changes. We reported a paraplegic man with skin ulcers on scretom and right foot after about 3 days of phenazopyridine use CASE REPORT: A 62-year-old man presented with flesh shaped deep ulcers in lower parts of the body. He declared that at first a bluish discoloration was developed in the lower extremities and scrotum skin after use of eight phenazopyridine tablets (200 mg) and then these lesions turned to blisters and ulcers and they were prurient. The patient underwent sonography and CT-angiography; however, no pathologic findings were found. He just received losartan for many years as past drug history. According to the history, a delayed drug hypersensitivity reaction was suspected and the patient wounds healed after using special type of dressings and antibiotic therapy regarding positive wound cultures.
CONCLUSIONS: Phenazopyridine severe skin changes are hardly reported. We described a case who experienced severe skin reactions and ulcers following phenazopyridine use not related to other complications including renal dysfunction, methemoglobinemia, and hemolytic anemia.
CONCLUSIONS: Phenazopyridine severe skin changes are hardly reported. We described a case who experienced severe skin reactions and ulcers following phenazopyridine use not related to other complications including renal dysfunction, methemoglobinemia, and hemolytic anemia.
摘要：
背景：苯并吡啶是一种偶氮染料，通过未知的机制对泌尿道粘膜发挥局部麻醉或镇痛作用。除了其常见的并发症，包括尿液的橙色变色和胃肠道问题，它可能有罕见的副作用，如溶血性贫血，高铁血红蛋白血症,肾功能衰竭,和皮肤变化。我们报道了一名截瘫男子，在使用非那唑吡啶约3天后，在屏幕和右脚上出现皮肤溃疡。他宣布，在使用八片非那唑吡啶片（200毫克）后，下肢和阴囊皮肤出现蓝色变色，然后这些病变变成水疱和溃疡，它们是瘙痒的。患者接受了超声检查和CT血管造影；然而，未发现病理结果.他刚刚接受氯沙坦多年作为过去的药物历史。根据历史,我们怀疑有迟发性药物超敏反应,在使用特殊类型的敷料和抗生素治疗阳性伤口培养后,患者伤口愈合.
结论：苯并吡啶严重的皮肤变化几乎没有报道。我们描述了一例在使用非那唑吡啶后出现严重皮肤反应和溃疡的病例，与包括肾功能不全在内的其他并发症无关。高铁血红蛋白血症,和溶血性贫血.
结论：苯并吡啶严重的皮肤变化几乎没有报道。我们描述了一例在使用非那唑吡啶后出现严重皮肤反应和溃疡的病例，与包括肾功能不全在内的其他并发症无关。高铁血红蛋白血症,和溶血性贫血.
