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Abstract：
OBJECTIVE: To analyze the development status, research hotspots, research frontiers and future development trends of the Notch signaling pathway in cancer through bibliometric analysis.
METHODS: Publications related to the Notch signaling pathway in cancer were obtained from the Web of Science Core Collection (WoSCC), and information was extracted from the articles using Microsoft Excel 2020, CiteSpace V and VOSviewer software for visual analysis.
RESULTS: The country and institution with the most publications are the USA and Harvard University, respectively. PLoS One is the most published journal, and Cancer Research is the most cocited journal. The author with the most published articles was L Miele, and the most cocited author was ZW Wang. The top 3 keywords were activation, differentiation and growth. Metastasis, epithelial-mesenchymal transition (EMT), invasion, target and resistance are the current research hotspots and frontiers in this field.
CONCLUSIONS: Research related to the Notch signaling pathway in cancer is currently booming, and the USA has made the greatest contribution to this field. At present, the research hotspots and research frontiers in this field mainly focus on the regulatory role of the Notch signaling pathway in tumor invasion and metastasis, the regulation of the Notch signaling pathway in tumor progression through EMT, and the participation of the Notch signaling pathway in the regulation of chemotherapy or immunotherapy resistance to tumors.
METHODS: Publications related to the Notch signaling pathway in cancer were obtained from the Web of Science Core Collection (WoSCC), and information was extracted from the articles using Microsoft Excel 2020, CiteSpace V and VOSviewer software for visual analysis.
RESULTS: The country and institution with the most publications are the USA and Harvard University, respectively. PLoS One is the most published journal, and Cancer Research is the most cocited journal. The author with the most published articles was L Miele, and the most cocited author was ZW Wang. The top 3 keywords were activation, differentiation and growth. Metastasis, epithelial-mesenchymal transition (EMT), invasion, target and resistance are the current research hotspots and frontiers in this field.
CONCLUSIONS: Research related to the Notch signaling pathway in cancer is currently booming, and the USA has made the greatest contribution to this field. At present, the research hotspots and research frontiers in this field mainly focus on the regulatory role of the Notch signaling pathway in tumor invasion and metastasis, the regulation of the Notch signaling pathway in tumor progression through EMT, and the participation of the Notch signaling pathway in the regulation of chemotherapy or immunotherapy resistance to tumors.
摘要：
目的：分析发展现状，研究热点,通过文献计量学分析,探讨Notch信号通路在肿瘤中的研究前沿和未来发展趋势。
方法：与癌症中的Notch信号通路相关的出版物来自WebofScienceCoreCollection（WoSCC），并使用MicrosoftExcel2020，CiteSpaceV和VOSviewer软件从文章中提取信息进行可视化分析。
结果：出版物最多的国家和机构是美国和哈佛大学，分别。PLoSOne是发表最多的期刊，癌症研究是最受欢迎的杂志。发表文章最多的作者是LMiele，最令人吃惊的作者是ZWWang。前3个关键词是激活,分化和增长。转移,上皮-间质转化（EMT），入侵,目标和阻力是当前该领域的研究热点和前沿。
结论：目前与癌症中的Notch信号通路相关的研究正在蓬勃发展，美国在这一领域做出了最大的贡献。目前,Notch信号通路在肿瘤侵袭转移中的调控作用,Notch信号通路通过EMT在肿瘤进展中的调控，Notch信号通路参与肿瘤化疗或免疫治疗耐药的调控。
方法：与癌症中的Notch信号通路相关的出版物来自WebofScienceCoreCollection（WoSCC），并使用MicrosoftExcel2020，CiteSpaceV和VOSviewer软件从文章中提取信息进行可视化分析。
结果：出版物最多的国家和机构是美国和哈佛大学，分别。PLoSOne是发表最多的期刊，癌症研究是最受欢迎的杂志。发表文章最多的作者是LMiele，最令人吃惊的作者是ZWWang。前3个关键词是激活,分化和增长。转移,上皮-间质转化（EMT），入侵,目标和阻力是当前该领域的研究热点和前沿。
结论：目前与癌症中的Notch信号通路相关的研究正在蓬勃发展，美国在这一领域做出了最大的贡献。目前,Notch信号通路在肿瘤侵袭转移中的调控作用,Notch信号通路通过EMT在肿瘤进展中的调控，Notch信号通路参与肿瘤化疗或免疫治疗耐药的调控。
