PDF(Pubmed)
Abstract：
UNASSIGNED: Multiple studies have demonstrated the medical potency of plant extracts and specific phytochemicals as therapeutics for prostate cancer (PCa) patients. Of note, the Neem plant known for its role as an antibiotic and anti-inflammatory is underexplored with an untapped potential for further development. This review focuses on extracts and phytochemicals derived from the Neem tree (Latin name; Azadirachta indica), commonly used throughout Southeast Asia for the prevention and treatment of a wide array of diseases including cancer. To date, there are more than 130 biologically active compounds that have been isolated from the Neem tree including azadirachtin, nimbolinin, nimbin, nimbidin, nimbidol, which have demonstrated a wide range of biological activities including anti-microbial, anti-fertility, anti-inflammatory, anti-arthritic, hepatoprotective, anti-diabetic, anti-ulcer, and anti-cancer effects. Very few scientific reports focus on the benefits of Neem in PCa, even though this herb has been used to prevent the disease and its progression for years in complementary and alternative medicine.
UNASSIGNED: We used the search engines like PubMed, InCommon and Google using the key words: \"Neem\", \"Cancer\", \"Prostate Cancer\" and related words to find the information and data within the time frame from 1980-2022 for our article study.
UNASSIGNED: Here, we provide an overview of Neem extracts and phytochemical derivatives with a focus on their known potential and ability to inhibit specific cellular signaling pathways and processes which drive PCa incidence and progression.
UNASSIGNED: The information presented here indicate that Neem and its derivatives have a therapeutic potential for the treatment of PCa when used as a single agent or in combination with conventional chemotherapeutics.
UNASSIGNED: We used the search engines like PubMed, InCommon and Google using the key words: \"Neem\", \"Cancer\", \"Prostate Cancer\" and related words to find the information and data within the time frame from 1980-2022 for our article study.
UNASSIGNED: Here, we provide an overview of Neem extracts and phytochemical derivatives with a focus on their known potential and ability to inhibit specific cellular signaling pathways and processes which drive PCa incidence and progression.
UNASSIGNED: The information presented here indicate that Neem and its derivatives have a therapeutic potential for the treatment of PCa when used as a single agent or in combination with conventional chemotherapeutics.
摘要：
■多项研究已经证明了植物提取物和特定植物化学物质作为前列腺癌（PCa）患者治疗剂的医学效力。值得注意的是，以其作为抗生素和消炎药的作用而闻名的印em植物尚未开发，具有未开发的进一步开发潜力。这篇综述的重点是源自印尼树（拉丁名；Azadirachtaindica）的提取物和植物化学物质，通常在整个东南亚用于预防和治疗包括癌症在内的各种疾病。迄今为止,有超过130种生物活性化合物已被分离出，包括印鉴素，nimbolinin,nimbin,Nimbidin,Nimbidol,已经证明了广泛的生物活性，包括抗微生物，抗生育,抗炎,抗关节炎,保肝,抗糖尿病，抗溃疡,和抗癌作用。很少有科学报告关注印尼红在PCa中的好处，尽管这种草药已被用于预防疾病和疾病的发展多年的补充和替代医学。
■我们使用了像PubMed这样的搜索引擎，InCommon和Google使用关键字：\“Neem\”，\"癌症\",“前列腺癌”和相关词语，为我们的文章研究找到1980-2022年时间范围内的信息和数据。
■这里，我们概述了印鉴提取物和植物化学衍生物，重点介绍了它们抑制导致PCa发生和发展的特定细胞信号通路和过程的已知潜力和能力。
此处提供的信息表明，当用作单一药物或与常规化学治疗剂组合使用时，Neem及其衍生物具有治疗PCa的治疗潜力。
■我们使用了像PubMed这样的搜索引擎，InCommon和Google使用关键字：\“Neem\”，\"癌症\",“前列腺癌”和相关词语，为我们的文章研究找到1980-2022年时间范围内的信息和数据。
■这里，我们概述了印鉴提取物和植物化学衍生物，重点介绍了它们抑制导致PCa发生和发展的特定细胞信号通路和过程的已知潜力和能力。
此处提供的信息表明，当用作单一药物或与常规化学治疗剂组合使用时，Neem及其衍生物具有治疗PCa的治疗潜力。
