Abstract：
Increasing attention has been paid to the biological roles of tripartite motif-containing (TRIM) family proteins, which typically function as E3 ubiquitin ligases. Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known as TRIM25, was originally identified as a protein induced by estrogen and plays critical roles in promoting endocrine-related cancers, including breast cancer, endometrial cancer, and prostate cancer. The pathophysiological importance of Efp made us interested in the roles of other TRIM family proteins that share a similar structure with Efp. Based on a phylogenetic analysis of the C-terminal region of TRIM family proteins, we focused on TRIM47 as a protein belonging to the same branch as Efp. TRIM47 is a poor prognostic factor in both breast cancer and prostate cancer. Atypical lysine-27-like poly-ubiquitination was involved in the underlying mechanism causing endocrine resistance in breast cancer. We also discuss the functions of Efp and TRIM47 in other types of cancers and innate immunity by introducing substrates the are modified by poly-ubiquitination.
摘要：
含三联基序（TRIM）家族蛋白的生物学作用受到越来越多的关注，通常充当E3泛素连接酶。雌激素反应性手指蛋白(Efp),TRIM家族蛋白的成员，也被称为TRIM25，最初被鉴定为由雌激素诱导的蛋白质，在促进内分泌相关癌症中起关键作用，包括乳腺癌,子宫内膜癌,和前列腺癌。Efp的病理生理学重要性使我们对与Efp具有相似结构的其他TRIM家族蛋白的作用感兴趣。基于TRIM家族蛋白C末端区域的系统发育分析,我们将TRIM47作为与EFP属于同一分支的蛋白质。TRIM47是乳腺癌和前列腺癌的不良预后因素。非典型赖氨酸-27样聚泛素化参与了导致乳腺癌内分泌抵抗的潜在机制。我们还通过引入通过聚泛素化修饰的底物来讨论Efp和TRIM47在其他类型的癌症和先天免疫中的功能。
