Abstract：
BACKGROUND: There is no consensus on which neonatal chart is best to use in very low birth weight (VLBW) infants. The aim of the study was to compare the Fenton 2013 and Intergrowth-21st (IW-21) charts based on their predictive ability for somatometry at 2 years, as well as to analyze factors related to short stature at 2 years.
METHODS: Cohort of children with VLBW born between 2002 and 2017. Association between neonatal somatometry (z-score by Fenton and IW-21) and risk of short stature (<-2 DS), head circumference <-2 DS and malnutrition at 2 years (BMI < -2 DS) was analyzed (WHO charts).
RESULTS: 513 children with a mean gestational age of 30.05 ± 2.5 weeks were included. Birth and discharge weight z-score by Fenton and IW-21 were useful for predicting risk of short stature and malnutrition at 2 years (without differences in the AUC of the ROC curves). Weight z-score at discharge was also useful for predicting head circumference < -2 DS. At 2 years, prevalence of short stature, head circumference < -2 DS, and malnutrition was 17.2, 4.1, and 6.1%, respectively. Low weight for gestational age and length of stay were identified as independent risk factors for short stature at 2 years.
CONCLUSIONS: Discharge weight z-score is useful for predicting risk of short stature, malnutrition and head circumference < -2 DS at 2 years in very low birth weight children, with no statistical difference between using Fenton or IW-21 charts.
METHODS: Cohort of children with VLBW born between 2002 and 2017. Association between neonatal somatometry (z-score by Fenton and IW-21) and risk of short stature (<-2 DS), head circumference <-2 DS and malnutrition at 2 years (BMI < -2 DS) was analyzed (WHO charts).
RESULTS: 513 children with a mean gestational age of 30.05 ± 2.5 weeks were included. Birth and discharge weight z-score by Fenton and IW-21 were useful for predicting risk of short stature and malnutrition at 2 years (without differences in the AUC of the ROC curves). Weight z-score at discharge was also useful for predicting head circumference < -2 DS. At 2 years, prevalence of short stature, head circumference < -2 DS, and malnutrition was 17.2, 4.1, and 6.1%, respectively. Low weight for gestational age and length of stay were identified as independent risk factors for short stature at 2 years.
CONCLUSIONS: Discharge weight z-score is useful for predicting risk of short stature, malnutrition and head circumference < -2 DS at 2 years in very low birth weight children, with no statistical difference between using Fenton or IW-21 charts.
摘要：
背景：对于在极低出生体重（VLBW）婴儿中最适合使用的新生儿图表尚无共识。该研究的目的是根据Fenton2013和Intergrowth-21st（IW-21）图表在2年时的体测量预测能力进行比较，以及分析与2年身材矮小相关的因素。
方法：2002年至2017年出生的VLBW儿童队列。新生儿躯体测量（Fenton和IW-21的z评分）与身材矮小（<-2DS）的风险之间的关联，分析头围<-2DS和2年营养不良(BMI<-2DS)(WHO图表)。
结果：纳入513名平均胎龄为30.05±2.5周的儿童。Fenton和IW-21的出生和出院体重z评分可用于预测2年时身材矮小和营养不良的风险（ROC曲线的AUC无差异）。出院时的体重z评分也可用于预测头围<-2DS。在2年,身材矮小的患病率，头围<-2DS,营养不良分别为17.2%、4.1%和6.1%，分别。胎龄低体重和住院时间被确定为2年身材矮小的独立危险因素。
结论：出院体重z评分可用于预测身材矮小的风险，极低出生体重儿童在2年时营养不良和头围<-2DS，使用Fenton或IW-21图表之间没有统计学差异。
方法：2002年至2017年出生的VLBW儿童队列。新生儿躯体测量（Fenton和IW-21的z评分）与身材矮小（<-2DS）的风险之间的关联，分析头围<-2DS和2年营养不良(BMI<-2DS)(WHO图表)。
结果：纳入513名平均胎龄为30.05±2.5周的儿童。Fenton和IW-21的出生和出院体重z评分可用于预测2年时身材矮小和营养不良的风险（ROC曲线的AUC无差异）。出院时的体重z评分也可用于预测头围<-2DS。在2年,身材矮小的患病率，头围<-2DS,营养不良分别为17.2%、4.1%和6.1%，分别。胎龄低体重和住院时间被确定为2年身材矮小的独立危险因素。
结论：出院体重z评分可用于预测身材矮小的风险，极低出生体重儿童在2年时营养不良和头围<-2DS，使用Fenton或IW-21图表之间没有统计学差异。
