Abstract：
OBJECTIVE: Genital warts are caused by the human papillomavirus (HPV), whose genotypes have traditionally been classified as low risk or high risk (oncogenic). The first 2 prophylactic vaccines included the most common genotypes at the time: HPV-6, HPV-11, HPV-16, and HPV-18. The aim of this study was to evaluate the prevalence of HPV types in our setting 10 years after the introduction of HPV vaccines.
METHODS: Descriptive, observational, retrospective study of patients diagnosed with genital warts at the sexually transmitted infection unit of a dermatology department between January 2016 and June 2019.
RESULTS: In total, 362 patients were diagnosed with genital warts during the study period, and 212 (58.6%) underwent genotyping. Thirty-two distinct HPV types were observed, the most common being HPV-6, HPV-11, HPV-16, and HPV-42. HPV DNA was detected in 93.9% of the samples analyzed, and there were 299 genotypes (mean, 1.5 per patient). Overall, 26.6% of patients had more than a single HPV genotype, while 24.1% had at least 1 high-risk type. No significant associations were found between the presence of high-risk HPV types and any of the study variables. At least 2 of the 4 HPV types targeted in the original vaccines were detected in 94.1% of lesions.
CONCLUSIONS: Compared to 10 years ago, the prevalences of HPV types included in the first 2 prophylactic vaccines have decreased, while the proportion of patients with at least 1 of the 4 most common types has remained unchanged. We also observed a slight increase in infections with multiple HPV types or at least 1 high-risk type.
METHODS: Descriptive, observational, retrospective study of patients diagnosed with genital warts at the sexually transmitted infection unit of a dermatology department between January 2016 and June 2019.
RESULTS: In total, 362 patients were diagnosed with genital warts during the study period, and 212 (58.6%) underwent genotyping. Thirty-two distinct HPV types were observed, the most common being HPV-6, HPV-11, HPV-16, and HPV-42. HPV DNA was detected in 93.9% of the samples analyzed, and there were 299 genotypes (mean, 1.5 per patient). Overall, 26.6% of patients had more than a single HPV genotype, while 24.1% had at least 1 high-risk type. No significant associations were found between the presence of high-risk HPV types and any of the study variables. At least 2 of the 4 HPV types targeted in the original vaccines were detected in 94.1% of lesions.
CONCLUSIONS: Compared to 10 years ago, the prevalences of HPV types included in the first 2 prophylactic vaccines have decreased, while the proportion of patients with at least 1 of the 4 most common types has remained unchanged. We also observed a slight increase in infections with multiple HPV types or at least 1 high-risk type.
摘要：
目的：生殖器疣是由人乳头瘤病毒（HPV）引起的，其基因型传统上被分类为低风险或高风险（致癌）。前2种预防性疫苗包括当时最常见的基因型:HPV-6、HPV-11、HPV-16和HPV-18。这项研究的目的是评估HPV疫苗引入10年后我们设定的HPV类型的患病率。
方法：描述性，观察,回顾性研究2016年1月至2019年6月在皮肤科性传播感染病房诊断为生殖器疣的患者.
结果：总计，362名患者在研究期间被诊断为生殖器疣，212例(58.6%)接受了基因分型。观察到32种不同的HPV类型，最常见的是HPV-6,HPV-11,HPV-16和HPV-42.在分析的样本中，有93.9%检测到HPVDNA，有299种基因型(平均值，每位患者1.5）。总的来说,26.6％的患者有多个单一的HPV基因型，而24.1%的患者至少有1种高危类型。在高危HPV类型的存在与任何研究变量之间没有发现显着关联。在94.1%的病变中检测到原始疫苗中靶向的4种HPV类型中的至少2种。
结论：与10年前相比，前2种预防性疫苗中包含的HPV类型的患病率有所下降，而4种最常见类型中至少有1种的患者比例保持不变。我们还观察到多种HPV类型或至少一种高危类型的感染略有增加。
方法：描述性，观察,回顾性研究2016年1月至2019年6月在皮肤科性传播感染病房诊断为生殖器疣的患者.
结果：总计，362名患者在研究期间被诊断为生殖器疣，212例(58.6%)接受了基因分型。观察到32种不同的HPV类型，最常见的是HPV-6,HPV-11,HPV-16和HPV-42.在分析的样本中，有93.9%检测到HPVDNA，有299种基因型(平均值，每位患者1.5）。总的来说,26.6％的患者有多个单一的HPV基因型，而24.1%的患者至少有1种高危类型。在高危HPV类型的存在与任何研究变量之间没有发现显着关联。在94.1%的病变中检测到原始疫苗中靶向的4种HPV类型中的至少2种。
结论：与10年前相比，前2种预防性疫苗中包含的HPV类型的患病率有所下降，而4种最常见类型中至少有1种的患者比例保持不变。我们还观察到多种HPV类型或至少一种高危类型的感染略有增加。
