Abstract：
Formaldehyde, one of the simplest reactive carbonyl substances, is involved in many physiological and pathological processes in living organisms. There is a large amount of data showing that abnormal elevation of formaldehyde is associated with a variety of diseases in the body, such as neurodegenerative diseases, Alzheimer\'s disease, cardiovascular diseases and cancer, and is also a representative carcinogen, so monitoring formaldehyde is of great importance for disease diagnosis and treatment. In this review, In this paper, we summarize and classify the last ten years of probes for the detection of formaldehyde according to different reaction mechanisms and discuss the structures and applications of the probes. Finally, we briefly describe the challenges and possible solutions in this field. We believe that more new probes provide powerful tools to study the function of formaldehyde in living systems.
摘要：
甲醛,一种最简单的活性羰基物质,参与生物体的许多生理和病理过程。有大量数据显示甲醛异常升高与体内多种疾病有关,如神经退行性疾病，老年痴呆症,心血管疾病和癌症，也是一种代表性的致癌物，因此监测甲醛对疾病的诊断和治疗具有重要意义。在这次审查中,在本文中,根据不同的反应机理，对近十年来检测甲醛的探针进行了总结和分类，并讨论了探针的结构和应用。最后,我们简要描述了该领域的挑战和可能的解决方案。我们相信，更多的新探针为研究甲醛在生命系统中的功能提供了强大的工具。
