PDF(Pubmed)
Abstract：
Coronavirus disease (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with systemic organ damage in the most severe forms. Long-term complications of SARS-CoV-2 appear to be restricted to severe presentations of COVID-19, but many patients with persistent symptoms have never been hospitalized. Post-acute sequelae of COVID-19 (PASC) represents a heterogeneous group of symptoms characterized by cardiovascular, general, respiratory, and neuropsychiatric sequelae. The pace of evidence acquisition with PASC has been rapid, but the mechanisms behind it are complex and not yet fully understood. In particular, exercise intolerance shares some features with other classic respiratory and cardiac disorders. However, cardiopulmonary exercise testing (CPET) provides a comprehensive assessment and can unmask the pathophysiological mechanism behind exercise intolerance in gray-zone PASC. This mini-review explores the utility of CPET and aims to provide a comprehensive assessment of PASC by summarizing the current evidence.
摘要：
冠状病毒病（COVID-19）是由严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）引起的传染病，最严重的全身性器官损伤。SARS-CoV-2的长期并发症似乎仅限于COVID-19的严重表现，但许多持续症状的患者从未住院。COVID-19急性后遗症（PASC）代表一组以心血管为特征的异质性症状，一般,呼吸,和神经精神后遗症。PASC的证据获取速度很快，但是它背后的机制很复杂，还没有完全理解。特别是,运动不耐受与其他典型的呼吸和心脏疾病有一些共同的特征。然而,心肺运动试验(CPET)提供了全面的评估,可以揭示灰区PASC中运动不耐受背后的病理生理机制.本小型审查探讨了CPET的效用，旨在通过总结当前证据对PASC进行全面评估。
