PDF(Pubmed)
Abstract：
Nanoparticles that contact human cells without damaging basic human tissues are becoming more widely used in medicine. Efficient delivery to the intracellular target cell or compartment through the cell membrane must be achieved with minimal cytotoxicity to healthy cells. Fe3O4 nanoparticles have been widely used in biomedical research for their magnetic, non-toxic, and biocompatible properties. However, the effects of Fe3O4 nanoparticles coated with chitosan (CS) on gynecological cells are unclear. In this study, the Fe3O4 nanoparticles were coated with CS to enhance their cytocompatibility and dispersion in water. These CS-Fe3O4 nanoparticles were taken up by gynecological cells and did not affect cell viability in vitro. They have greater cytocompatibility in acidic environments than normal Fe3O4 nanoparticles and have the potential for drug delivery into gynecological cells.
摘要：
在不损伤基本人体组织的情况下接触人细胞的纳米颗粒在医学中的应用越来越广泛。必须实现通过细胞膜向细胞内靶细胞或区室的有效递送,同时对健康细胞具有最小的细胞毒性。Fe3O4纳米粒子由于其磁性,在生物医学研究中得到了广泛的应用,无毒,和生物相容性。然而,壳聚糖（CS）包覆的Fe3O4纳米颗粒对妇科细胞的影响尚不清楚。在这项研究中,用CS包覆Fe3O4纳米颗粒以增强其细胞相容性和在水中的分散性。这些CS-Fe3O4纳米颗粒被妇科细胞吸收，并且在体外不影响细胞活力。它们在酸性环境中具有比普通Fe3O4纳米颗粒更大的细胞相容性，并且具有将药物递送到妇科细胞中的潜力。
