Abstract：
We report the case of a 46-year-old woman with Bloom-like syndrome affected with locally advanced cervical cancer. She was treated with induction chemotherapy and radical radiation therapy concurrent with chemotherapy (carboplatin and paclitaxel). She was able to complete treatment, but grade III toxicities were observed. The limited relevant literature is presented. We conclude that the management of patients with DNA repair deficiency is challenging for the team in charge because of the potentially high sensitivity to treatment and the lack of clear recommendations in the literature. The main objective remains to deliver the optimal treatment while reducing toxicities.
摘要：
我们报告了一名46岁的布卢姆样综合征女性，患有局部晚期宫颈癌。她在化疗（卡铂和紫杉醇）的同时接受诱导化疗和根治性放疗。她能够完成治疗，但观察到III级毒性。介绍了有限的相关文献。我们得出的结论是，由于对治疗的潜在高度敏感性以及文献中缺乏明确的建议，因此DNA修复缺陷患者的管理对负责团队具有挑战性。主要目标仍然是提供最佳治疗，同时减少毒性。
