PDF(Pubmed)
Abstract：
UNASSIGNED: Reinfection of human papillomavirus (HPV) among men who have sex with men (MSM) after clearing the infection of HPV has not been well characterized. To understand the reinfection of HPV among human immunodeficiency virus (HIV) negative MSM without HPV vaccine, we analyzed the reinfection of nine-valent HPV vaccine (9v-HPV) types.
UNASSIGNED: Data were acquired from a prospective cohort study among HIV-negative MSM in Urumqi of Xinjiang from 1 April 2016 to 14 July 2020. Participants were recruited through a local non-government organization using a website advertisement. Self-administered questionnaires and self-collected anal swabs were collected at baseline and every 6 months. The incidence rates of reinfection was calculated based on the number of events divided by person-months of observation of event risk. 95% confidence intervals (CIs) were calculated based on the Poisson distribution.
UNASSIGNED: A total of 515 HIV-negative unvaccinated MSM were included with a mean age of 30.93 years (SD 7.85), and 27.68% were reinfected with any 9v-HPV type after clearance. The reinfection incidence rate of any 9v-HPV was 14.47 per 1000 person-months (95% CI: 11.52-17.87). HPV52 was the most common type of reinfection, with a reinfection rate of 17.96 per 1,000 person months (95% CI: 11.58-26.33). Univariate analysis showed that MSM over the age of 30 had a slightly higher risk of reinfection with any 9v-HPV (Hazard ratio (HR): 1.57; 95% CI: 1.01-2.45), but no significant association was observed in multivariate analysis.
UNASSIGNED: Our study showed MSM without HPV vaccine will become reinfected following the natural clearance of specific HPV types. It is also suggested that HPV vaccination is recommended not only prior to sexual debut but also after viral clearance for MSM to reduce HPV prevalence.
UNASSIGNED: Data were acquired from a prospective cohort study among HIV-negative MSM in Urumqi of Xinjiang from 1 April 2016 to 14 July 2020. Participants were recruited through a local non-government organization using a website advertisement. Self-administered questionnaires and self-collected anal swabs were collected at baseline and every 6 months. The incidence rates of reinfection was calculated based on the number of events divided by person-months of observation of event risk. 95% confidence intervals (CIs) were calculated based on the Poisson distribution.
UNASSIGNED: A total of 515 HIV-negative unvaccinated MSM were included with a mean age of 30.93 years (SD 7.85), and 27.68% were reinfected with any 9v-HPV type after clearance. The reinfection incidence rate of any 9v-HPV was 14.47 per 1000 person-months (95% CI: 11.52-17.87). HPV52 was the most common type of reinfection, with a reinfection rate of 17.96 per 1,000 person months (95% CI: 11.58-26.33). Univariate analysis showed that MSM over the age of 30 had a slightly higher risk of reinfection with any 9v-HPV (Hazard ratio (HR): 1.57; 95% CI: 1.01-2.45), but no significant association was observed in multivariate analysis.
UNASSIGNED: Our study showed MSM without HPV vaccine will become reinfected following the natural clearance of specific HPV types. It is also suggested that HPV vaccination is recommended not only prior to sexual debut but also after viral clearance for MSM to reduce HPV prevalence.
摘要：
在清除HPV感染后与男性发生性关系的男性（MSM）中，人乳头瘤病毒（HPV）的再感染尚未得到很好的表征。了解未接种HPV疫苗的人类免疫缺陷病毒（HIV）阴性MSM中HPV的再感染情况。我们分析了9价HPV疫苗(9v-HPV)类型的再感染.
数据来自2016年4月1日至2020年7月14日新疆乌鲁木齐HIV阴性MSM的前瞻性队列研究。参与者是通过当地非政府组织使用网站广告招募的。在基线和每6个月收集自我管理问卷和自我收集的肛门拭子。再感染的发生率是根据事件数量除以事件风险观察的人-月计算的。95%置信区间(CI)基于泊松分布计算。
共纳入515名HIV阴性未接种疫苗的MSM，平均年龄为30.93岁（SD7.85），27.68%的人在清除后再次感染任何9v-HPV类型。任何9v-HPV的再感染发生率为14.47/1000人-月（95％CI：11.52-17.87）。HPV52是最常见的再感染类型,再感染率为17.96/1000人月（95%CI：11.58-26.33）。单因素分析显示，30岁以上的MSM再次感染任何9v-HPV的风险略高（危险比（HR）：1.57;95％CI：1.01-2.45），但在多变量分析中未观察到显著关联.
我们的研究表明，没有HPV疫苗的MSM将在特定HPV类型的自然清除后再次感染。还建议不仅在首次性行为之前，而且在MSM的病毒清除之后，都建议接种HPV疫苗，以减少HPV的流行。
数据来自2016年4月1日至2020年7月14日新疆乌鲁木齐HIV阴性MSM的前瞻性队列研究。参与者是通过当地非政府组织使用网站广告招募的。在基线和每6个月收集自我管理问卷和自我收集的肛门拭子。再感染的发生率是根据事件数量除以事件风险观察的人-月计算的。95%置信区间(CI)基于泊松分布计算。
共纳入515名HIV阴性未接种疫苗的MSM，平均年龄为30.93岁（SD7.85），27.68%的人在清除后再次感染任何9v-HPV类型。任何9v-HPV的再感染发生率为14.47/1000人-月（95％CI：11.52-17.87）。HPV52是最常见的再感染类型,再感染率为17.96/1000人月（95%CI：11.58-26.33）。单因素分析显示，30岁以上的MSM再次感染任何9v-HPV的风险略高（危险比（HR）：1.57;95％CI：1.01-2.45），但在多变量分析中未观察到显著关联.
我们的研究表明，没有HPV疫苗的MSM将在特定HPV类型的自然清除后再次感染。还建议不仅在首次性行为之前，而且在MSM的病毒清除之后，都建议接种HPV疫苗，以减少HPV的流行。
