Abstract：
The main goal of periodontology is to prevent and arrest gingivitis and periodontitis to avoid tooth loss and focal infection of periodontal origin. Periodontal scaling or flap surgery of moderate-to-severe periodontitis have shortcomings, most likely because removal of herpesviruses and bacterial pathogens in deep periodontal lesions and the adjacent inflamed gingiva requires systemic antimicrobial treatment (or gingivectomy). Valacyclovir (1000 mg twice daily on day 1, and 500 mg twice daily on day 2 and on day 3) is a potent anti-herpesvirus agent. Antibiotic combinations against bacterial pathogens include amoxicillin-metronidazole (250 mg of each, thrice daily for 4 days; for systemically healthy adults) and ciprofloxacin-metronidazole (500 mg of each, twice daily for 4 days; for immunosuppressed individuals and patients exposed to contaminated water and poor sanitation). Supportive antiseptic treatment may consist of 0.1%-0.2% sodium hypochlorite (regular household bleach) as cooling spray in ultrasonic scalers, flosser fluid in oral irrigators, and mouthrinse in patient self-care. The anti-infective treatment described here helps control cases of severe periodontitis and constitutes an exceedingly inexpensive alternative to conventional (mechanical) periodontal therapy.
摘要：
牙周学的主要目标是预防和阻止牙龈炎和牙周炎，以避免牙齿脱落和牙周起源的局灶性感染。中重度牙周炎的牙周刮除或皮瓣手术有缺点，最可能的原因是去除深层牙周病和邻近发炎的牙龈中的疱疹病毒和细菌病原体需要全身抗菌治疗（或牙龈切除术）。伐昔洛韦（第1天每天两次1000毫克，第2天和第3天每天两次500毫克）是一种有效的抗疱疹病毒剂。针对细菌病原体的抗生素组合包括阿莫西林-甲硝唑（每种250毫克，每天三次，持续4天；对于系统健康的成年人）和环丙沙星-甲硝唑（每个500毫克，每天两次，共4天；对于免疫抑制个体和暴露于污染水和卫生条件差的患者）。支持性防腐处理可包括0.1%-0.2%的次氯酸钠（普通家用漂白剂）作为超声波洁牙机的冷却喷雾，口腔冲洗器中的牙线流体，和病人自我护理的漱口水。此处描述的抗感染治疗有助于控制严重牙周炎的病例，并且是常规（机械）牙周治疗的极其廉价的替代方案。
