Abstract：
Long considered as no more than biological waste meant to be eliminated in urine, glucuronides have recently contributed to tremendous developments in the biomedical field, particularly against cancer. While glucuronide prodrugs monotherapy and antibody-directed enzyme prodrug therapy have been around for some time, new facets have emerged that combine the unique properties of glucuronides notably in the fields of antibody-drug conjugates and nanomedicine. In both cases, glucuronides are utilized as a vector to improve pharmacokinetics and confer localized activation of potent drugs at tumor sites while also decreasing systemic toxicity. Here we will discuss some of the most promising strategies using glucuronides to promote successful anti-tumor therapeutic treatments.
摘要：
长期以来，人们认为这只不过是将生物废物排除在尿液中，葡萄糖醛酸最近在生物医学领域的巨大发展做出了贡献，特别是针对癌症。虽然葡糖苷酸前药单一疗法和抗体导向的酶前药疗法已经存在了一段时间，新的方面已经出现，结合了葡萄糖醛酸苷的独特特性，特别是在抗体-药物缀合物和纳米医学领域。在这两种情况下，葡糖醛酸被用作载体以改善药代动力学并赋予有效药物在肿瘤部位的局部激活,同时还降低全身毒性。在这里，我们将讨论一些最有前途的策略使用葡糖醛酸来促进成功的抗肿瘤治疗治疗。
