Abstract：
Witkop tooth and nail syndrome is a rare, autosomal dominant type of ectodermal dysplasia that can have significant effects on dentition, including hypoplastic and malformed dentition and significantly atrophic maxillas. Endosseous implants have become one possible solution to replace missing teeth, although their use in areas where bone is sparse becomes challenging. Due to the severe atrophy of the maxillary alveolus, extensive preprosthetic surgeries including orthognathic surgery, extensive bone grafting, and sinus floor augmentations have been recommended prior to placement of endosseous dental implants. Although this treatment has shown favorable outcomes, it requires multiple surgical procedures, contributing to a prolonged treatment course and increased morbidity. An alternative treatment of atrophic maxillas in patients with ectodermal dysplasia includes the use of zygomatic implants. This familial case series discusses 3 siblings, all previously diagnosed with Witkop Syndrome, who underwent comprehensive preprosthetic surgery and prosthetic rehabilitation using zygomatic implants with a follow-up period up to 15 years.
摘要：
Witkop牙齿和指甲综合征是一种罕见的，常染色体显性遗传类型的外胚层发育不良，可以对牙列产生重大影响，包括发育不全和畸形的牙列和明显萎缩的上颌骨。骨内植入物已成为替代缺失牙齿的一种可能解决方案，尽管它们在骨骼稀疏的区域的使用变得具有挑战性。由于上颌牙槽的严重萎缩,广泛的假体前手术，包括正颌手术，广泛的骨移植，建议在放置骨内牙科植入物之前进行窦底扩张。虽然这种治疗已经显示出良好的效果，它需要多个外科手术,有助于延长疗程和增加发病率。外胚层发育不良患者萎缩性上颌骨的替代治疗包括使用zy骨植入物。这个家族案例系列讨论了三个兄弟姐妹，之前都被诊断出患有Witkop综合征,他们接受了全面的假体前手术和使用zy骨植入物的假体康复，随访期长达15年。
