Abstract：
Mechanosensitive Piezo ion channels were first reported in 2010 in a mouse neuroblastoma cell line, opening up a new field for studying the composition and function of eukaryotic mechanically activated channels. During the past decade, Piezo ion channels were identified in many species, such as bacteria, Drosophila, and mammals. In mammals, basic life activities, such as the sense of touch, proprioception, hearing, vascular development, and blood pressure regulation, depend on the activation of Piezo ion channels. Cumulative evidence suggests that Piezo ion channels play a major role in lung vascular development and function and diseases like pneumonia, pulmonary hypertension, apnea, and other lung-related diseases. In this review, we focused on studies that reported specific functions of Piezos in tissues and emphasized the physiological and pathological effects of their absence or functional mutations on the respiratory system.
摘要：
机械敏感性压电离子通道于2010年首次在小鼠神经母细胞瘤细胞系中报道，开辟了研究真核机械激活通道的组成和功能的新领域。在过去的十年里，在许多物种中发现了压电离子通道，如细菌，果蝇,和哺乳动物。在哺乳动物中,基本的生命活动，比如触觉，本体感受,听力,血管发育,和血压调节，依赖于压电离子通道的激活。累积证据表明，压电离子通道在肺血管发育和功能以及肺炎等疾病中起主要作用，肺动脉高压,呼吸暂停,和其他肺部相关疾病。在这次审查中,我们专注于报道组织中Piezos特定功能的研究,并强调其缺失或功能突变对呼吸系统的生理和病理影响.
