UNASSIGNED: Conventional karyotyping and fluorescence in situ hybridization and/or spectral karyotyping of the pretreatment bone marrow aspirate of de novo AML patients were performed to delineate chromosomal abnormalities.
UNASSIGNED: We identified three cases with novel variants of t(8;21); der(13)t(8;21;13), isodicentric derivative 8 with chromosome 21[,+idicder(8)(q11.1)t(8;21)(q22;q11.1)] and der(21)t(8;12;21)(q22;q?;q22).
UNASSIGNED: AML with t(8;21)(q22;q22);RUNX1-RUNX1T1 forms a distinct WHO subcategory and hence the identification of variants or unusual translocations associated with t(8;21) deserves more attention. Contribution to the variant/ unusual t(8;21) database will further refine the risk stratification and may help to significantly advance the current treatment regimen.
■对初发AML患者的预处理骨髓抽吸物进行常规核型分析和荧光原位杂交和/或光谱核型分析,以描绘染色体异常。
■我们确定了三个具有t(8;21);der(13)t(8;21;13)新变体的病例,具有21号染色体的8号等中心衍生物[,+idicder(8)(q11.1)t(8;21)(q22;q11.1)]和der(21)t(8;12;21)(q22;q?;q22)。
■AML伴t(8;21)(q22;q22);RUNX1-RUNX1T1构成独特的WHO亚类,因此与t(8;21)相关的变异或异常易位的鉴定值得更多关注。对变异/异常t(8;21)数据库的贡献将进一步完善风险分层,并可能有助于显着推进当前的治疗方案。