Abstract：
The use of rocuronium/sugammadex in otorhinolaryngologic surgery improves intubation conditions and surgical rating scales. This study primarily aimed to evaluate the effect of the combination of rocuronium and sugammadex on intraoperative anesthetic consumption. The secondary outcomes were the intraoperative and postoperative morphine milligram equivalent (MME) consumption, duration of intraoperative hypertension, extubation time, incidence of delayed extubation and postoperative nausea and vomiting, pain score, and length of stay. A total of 2848 patients underwent otorhinolaryngologic surgery at a tertiary medical center in southern Taiwan. After applying the exclusion criteria, 2648 of these cases were included, with 167 and 2481 in the rocuronium/sugammadex and cisatracurium/neostigmine groups, respectively. To reduce potential bias, 119 patients in each group were matched by propensity scores for sex, age, body weight, and type of surgery. We found that the rocuronium/sugammadex group was associated with significant preservation of the intraoperative sevoflurane and MME consumption, with reductions of 14.2% (p = 0.009) and 11.8% (p = 0.035), respectively. The use of the combination of rocuronium and sugammadex also significantly increased the dose of intraoperative labetalol (p = 0.002), although there was no significant difference in intraoperative hypertensive events between both groups. In conclusion, our results may encourage the use of the combination of rocuronium and sugammadex as part of volatile-sparing and opioid-sparing anesthesia in otorhinolaryngologic surgery.
摘要：
罗库溴铵/Sugammadex在耳鼻咽喉科手术中的使用改善了插管条件和手术评定量表。这项研究的主要目的是评估罗库溴铵和Sugammadex的组合对术中麻醉消耗的影响。次要结果是术中和术后吗啡毫克当量（MME）消耗量，术中高血压的持续时间，拔管时间,延迟拔管和术后恶心呕吐的发生率，疼痛评分,和逗留时间的长短。共有2848名患者在台湾南部的三级医疗中心接受了耳鼻喉手术。应用排除标准后，其中2648例包括在内，在罗库溴铵/sugamadex和顺式阿曲库铵/新斯的明组中有167和2481，分别。为了减少潜在的偏差，每组119例患者根据性别倾向评分进行匹配，年龄,体重,和手术类型。我们发现罗库溴铵/sugammadex组与术中七氟醚和MME消耗的显著保留相关，减少14.2%(p=0.009)和11.8%(p=0.035)，分别。使用罗库溴铵和sugammadex的组合也显着增加了术中拉贝洛尔的剂量（p=0.002），尽管两组之间术中高血压事件无显著差异.总之,我们的研究结果可能鼓励在耳鼻咽喉手术中使用罗库溴铵和Sugammadex联合使用作为挥发性物质节约和阿片类物质节约麻醉的一部分.
