Abstract：
Becker\'s nevus (BN) is a cutaneous hamartoma of benign nature that develops through adolescence and affects mostly young men. The nevus is usually located unilaterally and is characterized by hypertrichosis and hyperpigmentation. Despite recent advances in treatment modalities, no effective treatment has been established for BN hyperpigmentation. We sought to assess the efficacy and safety of fractional Erbium: YAG 2940 nm and Q-switched Nd: YAG 1064 nm lasers in the treatment of BN hyperpigmentation. Twenty-three patients with BN were included in a prospective, randomized-controlled, observer-blinded, split-lesion comparative technique trial. In each patient, two similar square test regions were randomized to either be treated with a fractional Erbium: YAG 2940 nm laser or with a Q-switched Nd: YAG 1064 nm laser. Each patient was treated with three sessions at six-week intervals. At the follow-up, clearance of hyperpigmentation was assessed by physician global assessment, visual analogue scale, grade of improvement, patient global assessment, and patient satisfaction. Regions treated with the fractional Erbium: YAG 2940 nm laser demonstrated significantly better improvement compared to ones treated with the Q-switched Nd: YAG 1064 nm (p-value = 0.001) laser. Adverse effects such as repigmentation and hypertrophic scarring were not reported during the follow-up period. The outcomes were cosmetically acceptable with overall high satisfaction among the included patients. Our data suggest a superior role for the fractional Erbium: YAG (2940 nm) laser in the treatment of BN hyperpigmentation compared to the Q-switched Nd: YAG (1064 nm) laser, along with being a safer method and having no reported side effects.
摘要：
贝克尔痣（BN）是一种良性的皮肤错构瘤，在青春期发展，主要影响年轻男性。痣通常位于单侧，其特征是多毛症和色素沉着过度。尽管最近在治疗方式上取得了进展，尚未建立有效的BN色素沉着治疗方法。我们试图评估分数铒：YAG2940nm和调QNd：YAG1064nm激光治疗BN色素沉着过度的有效性和安全性。23例BN患者被纳入前瞻性研究，随机对照,观察者失明,分裂病变比较技术试验。在每个病人中,两个相似的正方形测试区域被随机分配使用分数铒:YAG2940nm激光或Q开关Nd:YAG1064nm激光进行处理.每个患者以六周的间隔进行三次治疗。在后续行动中，色素沉着过度的清除是通过医生的整体评估来评估的。视觉模拟量表,改进的等级，患者全球评估，患者满意度。与用Q开关Nd:YAG1064nm(p值=0.001)激光处理的区域相比,用分数铒:YAG2940nm激光处理的区域显示出显著更好的改善。随访期间未报告色素沉着和肥厚性瘢痕形成等不良反应。结果在美容上是可以接受的，在纳入的患者中总体满意度很高。我们的数据表明，与Q开关Nd：YAG（1064nm）激光相比，分数铒：YAG（2940nm）激光在治疗BN色素沉着中的作用更好。同时是一种更安全的方法，没有报道的副作用。
