Abstract：
Currently, data regarding the impact of COVID-19 disease (caused by SARS-CoV-2) on patients with childhood rheumatic diseases are significantly limited. To assess the possible connection, we measured levels of IgA and IgG anti-SARS-CoV-2 antibodies in children with juvenile idiopathic arthritis (JIA) and a control group during the pandemic, prior to the introduction of anti-COVID-19 vaccination. We assessed levels of PD-1 suppressive molecule and inflammatory markers in patients and correlated those results with serological response to SARS-CoV-2. In JIA patients, the activity of the disease was assessed using the Juvenile Arthritis Disease Activity Score 71 (JADAS 71) scale. The study consisted of 96 children, 65 diagnosed with JIA, treated with antirheumatic drugs, and 31 healthy volunteers. In patients with JIA, significantly higher levels of SARS-CoV-2 antibodies in the IgA and IgG were demonstrated compared to the control group. We also found significantly higher serum PD-1 levels in JIA patients and control volunteers who were seropositive for SARS-CoV-2 IgA or IgG antibodies compared to those who were seronegative. The humoral immune response to SARS-CoV-2 infection is associated with the persistent upregulation of PD-1 expression in both JIA patients and healthy children. The clinical significance of the detected disorder requires further careful observation.
摘要：
目前,关于COVID-19疾病(由SARS-CoV-2引起)对儿童风湿性疾病患者的影响的数据非常有限.为了评估可能的联系，我们测量了大流行期间幼年特发性关节炎（JIA）儿童和对照组的IgA和IgG抗SARS-CoV-2抗体水平，在引入抗COVID-19疫苗接种之前。我们评估了患者中PD-1抑制分子和炎症标志物的水平，并将这些结果与对SARS-CoV-2的血清学反应相关联。在JIA患者中，使用青少年关节炎疾病活动度评分71(JADAS71)量表评估疾病活动度.这项研究由96名儿童组成，65被诊断为JIA，用抗风湿药治疗，31名健康志愿者在JIA患者中，与对照组相比，IgA和IgG中的SARS-CoV-2抗体水平显着升高。我们还发现，与血清阴性者相比，SARS-CoV-2IgA或IgG抗体血清阳性的JIA患者和对照志愿者的血清PD-1水平明显更高。对SARS-CoV-2感染的体液免疫应答与JIA患者和健康儿童中PD-1表达的持续上调有关。检测到的疾病的临床意义需要进一步仔细观察。
