Abstract：
Second messenger cyclic adenosine monophosphate (cAMP) has been found to regulate multiple mitochondrial functions, including respiration, dynamics, reactive oxygen species production, cell survival and death through the activation of cAMP-dependent protein kinase A (PKA) and other effectors. Several members of the large family of A kinase anchor proteins (AKAPs) have been previously shown to locally amplify cAMP/PKA signaling to mitochondria, promoting the assembly of signalosomes, regulating multiple cardiac functions under both physiological and pathological conditions. In this review, we will discuss roles and regulation of major mitochondria-targeted AKAPs, along with opportunities and challenges to modulate their functions for translational purposes in the cardiovascular system.
摘要：
已发现第二信使环磷酸腺苷（cAMP）调节多种线粒体功能，包括呼吸,动力学,活性氧的产生，通过激活cAMP依赖性蛋白激酶A（PKA）和其他效应子，细胞存活和死亡。A激酶锚定蛋白（AKAP）大家族的几个成员先前已被证明可以局部扩增cAMP/PKA信号传导到线粒体，促进信号体的组装，在生理和病理条件下调节多种心脏功能。在这次审查中,我们将讨论主要线粒体靶向AKAP的作用和调节，以及在心血管系统中为翻译目的调节其功能的机遇和挑战。
