PDF(Pubmed)
Abstract：
The aetiology of peripartum cardiomyopathy (PPCM) is still not clear, and it is unknown who would recover from PPCM. In this meta-analysis, for the first time, we aimed to explore the prognostic value of potential baseline factors that may help predict recovery in patients with PPCM.
A systematic approach following the Meta-analysis of Observational Studies in Epidemiology guideline was taken by using appropriate keywords in PubMed, Scopus, and Embase databases. Studies that had compared different clinical and paraclinical markers at the time of diagnosis related to cardiovascular function between recovered and non-recovered patients with PPCM were included. To find potential predictors of recovery, the odds ratio (OR) was calculated for different parameters using the random-effects model.
Eighteen cohort studies including 1047 patients with PPCM were enrolled. Six markers out of the 11 potentially eligible markers were associated with PPCM recovery. Baseline echocardiographic parameters [left ventricular ejection fraction (LVEF) (OR = 4.84 [2.53; 9.26]), left ventricular end-diastolic diameter (OR = 3.67 [2.58; 5.23]), left ventricular end-systolic diameter (OR = 3.99 [2.27; 7.02]), and fractional shortening (OR = 6.14 [1.81; 20.85])] were strong predictors of PPCM recovery. Systolic blood pressure (OR = 2.16 [1.38; 3.38]) and diastolic blood pressure (OR = 2.06 [1.07; 3.96]) at diagnosis were also associated with recovery.
Patients with PPCM who have a higher baseline LVEF, lower left ventricular diameters, and higher blood pressure levels have a greater chance to recover from PPCM.
A systematic approach following the Meta-analysis of Observational Studies in Epidemiology guideline was taken by using appropriate keywords in PubMed, Scopus, and Embase databases. Studies that had compared different clinical and paraclinical markers at the time of diagnosis related to cardiovascular function between recovered and non-recovered patients with PPCM were included. To find potential predictors of recovery, the odds ratio (OR) was calculated for different parameters using the random-effects model.
Eighteen cohort studies including 1047 patients with PPCM were enrolled. Six markers out of the 11 potentially eligible markers were associated with PPCM recovery. Baseline echocardiographic parameters [left ventricular ejection fraction (LVEF) (OR = 4.84 [2.53; 9.26]), left ventricular end-diastolic diameter (OR = 3.67 [2.58; 5.23]), left ventricular end-systolic diameter (OR = 3.99 [2.27; 7.02]), and fractional shortening (OR = 6.14 [1.81; 20.85])] were strong predictors of PPCM recovery. Systolic blood pressure (OR = 2.16 [1.38; 3.38]) and diastolic blood pressure (OR = 2.06 [1.07; 3.96]) at diagnosis were also associated with recovery.
Patients with PPCM who have a higher baseline LVEF, lower left ventricular diameters, and higher blood pressure levels have a greater chance to recover from PPCM.
摘要：
围产期心肌病(PPCM)的病因尚不明确,不知道谁会从PPCM康复。在这个荟萃分析中，第一次,我们旨在探讨可能有助于预测PPCM患者康复的潜在基线因素的预后价值.
在流行病学指南中观察性研究的荟萃分析之后，通过使用PubMed中的适当关键词采取了系统的方法，Scopus,和Embase数据库。包括在诊断时比较了康复和未康复的PPCM患者与心血管功能相关的不同临床和临床旁标记的研究。为了找到潜在的恢复预测因子，使用随机效应模型计算不同参数的比值比(OR).
纳入18项队列研究，包括1047例PPCM患者。11个潜在合格标记中的6个标记与PPCM恢复相关。基线超声心动图参数[左心室射血分数(LVEF)(OR=4.84[2.53;9.26]),左心室舒张末期内径（OR=3.67[2.58;5.23]），左心室收缩末期内径（OR=3.99[2.27;7.02]），和分数缩短(OR=6.14[1.81;20.85])]是PPCM恢复的有力预测因子。诊断时收缩压（OR=2.16[1.38;3.38]）和舒张压（OR=2.06[1.07;3.96]）也与恢复有关。
PPCM患者基线LVEF较高，左心室下直径，和更高的血压水平有更大的机会从PPCM恢复。
在流行病学指南中观察性研究的荟萃分析之后，通过使用PubMed中的适当关键词采取了系统的方法，Scopus,和Embase数据库。包括在诊断时比较了康复和未康复的PPCM患者与心血管功能相关的不同临床和临床旁标记的研究。为了找到潜在的恢复预测因子，使用随机效应模型计算不同参数的比值比(OR).
纳入18项队列研究，包括1047例PPCM患者。11个潜在合格标记中的6个标记与PPCM恢复相关。基线超声心动图参数[左心室射血分数(LVEF)(OR=4.84[2.53;9.26]),左心室舒张末期内径（OR=3.67[2.58;5.23]），左心室收缩末期内径（OR=3.99[2.27;7.02]），和分数缩短(OR=6.14[1.81;20.85])]是PPCM恢复的有力预测因子。诊断时收缩压（OR=2.16[1.38;3.38]）和舒张压（OR=2.06[1.07;3.96]）也与恢复有关。
PPCM患者基线LVEF较高，左心室下直径，和更高的血压水平有更大的机会从PPCM恢复。
