Abstract：
Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with severe social communication, interaction, and sensory processing impairments. Efforts to understand its etiology and pathophysiology are crucial for improving treatment and prevention measures. Preclinical models of ASD are essential for investigating the biological mechanisms and should present translatability potential. We aim to evaluate the consistency of the most commonly used rodent models of ASD in displaying autistic-like behavior through a systematic review and meta-analysis.
This review will focus on the most frequently used autism models, surveying studies of six genetic (Ube3a, Pten, Nlgn3, Shank3, Mecp2, and Fmr1), three chemically induced (valproic acid (VPA), lipopolysaccharide (LPS), and polyinosinic:polycytidylic acid (poly(I:C))), and one inbred model (BTBR T+ Itpr3tf/J mouse strain). Two independent reviewers will screen the records. Data extraction of behavioral outcomes and risk of bias evaluation will be performed. We will conduct a meta-analysis whenever at least five studies investigate the same model and behavioral outcome. We will also explore the heterogeneity and publication bias. Network meta-analyses are planned to compare different models.
By shortening the gap between animal behavior and human endophenotypes or specific clinical symptoms, we expect to help researchers on which rodent models are adequate for research of specific behavioral manifestations of autism, which potentially require a combination of them depending on the research interest.
PROSPERO CRD42021226299 .
This review will focus on the most frequently used autism models, surveying studies of six genetic (Ube3a, Pten, Nlgn3, Shank3, Mecp2, and Fmr1), three chemically induced (valproic acid (VPA), lipopolysaccharide (LPS), and polyinosinic:polycytidylic acid (poly(I:C))), and one inbred model (BTBR T+ Itpr3tf/J mouse strain). Two independent reviewers will screen the records. Data extraction of behavioral outcomes and risk of bias evaluation will be performed. We will conduct a meta-analysis whenever at least five studies investigate the same model and behavioral outcome. We will also explore the heterogeneity and publication bias. Network meta-analyses are planned to compare different models.
By shortening the gap between animal behavior and human endophenotypes or specific clinical symptoms, we expect to help researchers on which rodent models are adequate for research of specific behavioral manifestations of autism, which potentially require a combination of them depending on the research interest.
PROSPERO CRD42021226299 .
摘要：
自闭症谱系障碍（ASD）是一种与严重的社交交流相关的神经发育状况，互动,和感官加工障碍。努力了解其病因和病理生理学对于改善治疗和预防措施至关重要。ASD的临床前模型对于研究生物学机制至关重要，并且应具有可翻译潜力。我们旨在通过系统评价和荟萃分析评估最常用的ASD啮齿动物模型在显示自闭症样行为方面的一致性。
这篇综述将集中在最常用的自闭症模型上，六个遗传的调查研究(Ube3a，Pten,Nlgn3、Shank3、Mecp2和Fmr1)，三化学诱导(丙戊酸(VPA)，脂多糖（LPS），和聚肌苷酸：聚胞苷酸（聚（I：C）），和一个近交模型(BTBRT+Itpr3tf/J小鼠品系)。两名独立的审阅者将筛选记录。将进行行为结果的数据提取和偏见风险评估。每当至少有五项研究调查相同的模型和行为结果时，我们将进行荟萃分析。我们还将探讨异质性和发表偏倚。网络荟萃分析计划比较不同的模型。
通过缩短动物行为与人类内表型或特定临床症状之间的差距，我们希望帮助研究人员研究哪种啮齿动物模型足以研究自闭症的特定行为表现，这可能需要它们的组合，这取决于研究兴趣。
PROSPEROCRD42021226299。
这篇综述将集中在最常用的自闭症模型上，六个遗传的调查研究(Ube3a，Pten,Nlgn3、Shank3、Mecp2和Fmr1)，三化学诱导(丙戊酸(VPA)，脂多糖（LPS），和聚肌苷酸：聚胞苷酸（聚（I：C）），和一个近交模型(BTBRT+Itpr3tf/J小鼠品系)。两名独立的审阅者将筛选记录。将进行行为结果的数据提取和偏见风险评估。每当至少有五项研究调查相同的模型和行为结果时，我们将进行荟萃分析。我们还将探讨异质性和发表偏倚。网络荟萃分析计划比较不同的模型。
通过缩短动物行为与人类内表型或特定临床症状之间的差距，我们希望帮助研究人员研究哪种啮齿动物模型足以研究自闭症的特定行为表现，这可能需要它们的组合，这取决于研究兴趣。
PROSPEROCRD42021226299。
