METHODS: This case-control study included unaffected OBD (mean age 14.0 years; male 50.0 %) and age- and sex-matched OCP (mean age 13.0 years; male: 43.5 %). Seventeen saliva samples were collected in dim light conditions. Dim light melatonin onset (DLMO), phase angles, and area under the curve (AUC) were calculated.
RESULTS: 185 saliva samples from 12 OBD (n = 12) and 741 from OCP (n = 46) were collected. Unaffected OBD had a significant lower nocturnal melatonin level (14.8 ± 4.6 vs. 20.3 ± 11.7 pg/mL) and a smaller melatonin AUC within two hours after DLMO (35.5 ± 11.3 vs. 44.6 ± 18.1 pg/mL) but a significant larger phase angle between DLMO and sleep onset (2.2 ± 1.0 vs. 1.4 ± 1.2 h) than OCP. There was no significant between-group difference in DLMO. The graphic illustrations showed a considerably flattened melatonin secretion in unaffected OBD.
CONCLUSIONS: The main limitations include lack of 24-h dim melatonin secretion measurement, large age range of participants, and small sample size.
CONCLUSIONS: These findings suggest that unaffected OBD already presented with circadian rhythm dysregulations. Future investigations are needed to clarify the role of abnormal melatonin secretion in the onset of BD.
方法:本病例对照研究包括未受影响的OBD(平均年龄14.0岁;男性50.0%)和年龄和性别匹配的OCP(平均年龄13.0岁;男性:43.5%)。在暗光条件下收集十七个唾液样品。弱光褪黑激素(DLMO),相位角,计算曲线下面积(AUC)。
结果:收集了来自12个OBD(n=12)的185个唾液样品和来自OCP(n=46)的741个唾液样品。未受影响的OBD夜间褪黑激素水平显着降低(14.8±4.6vs.20.3±11.7pg/mL)和DLMO后两小时内较小的褪黑激素AUC(35.5±11.3vs.44.6±18.1pg/mL),但DLMO和睡眠开始之间的相位角明显更大(2.2±1.0vs.1.4±1.2h)比OCP高。DLMO组间差异无统计学意义。图形说明显示未受影响的OBD中褪黑激素分泌相当平坦。
结论:主要限制包括缺乏24小时昏暗的褪黑激素分泌测量,参与者的年龄范围很大,样本量小。
结论:这些研究结果表明未受影响的OBD已经出现昼夜节律失调。需要进一步的研究来阐明褪黑激素分泌异常在BD发作中的作用。