Abstract:
Cardiac remodelling is characterized by abnormal changes in the function and morphological properties such as diameter, mass, normal diameter of cavities, heart shape, fibrosis, thickening of vessels and heart layers, cardiomyopathy, infiltration of inflammatory cells, and some others. These damages are associated with damage to systolic and diastolic abnormalities, damage to ventricular function, and vascular remodelling, which may lead to heart failure and death. Exposure of the heart to radiation or anti-cancer drugs including chemotherapy drugs such as doxorubicin, receptor tyrosine kinase inhibitors (RTKIs) such as imatinib, and immune checkpoint inhibitors (ICIs) can induce several abnormal changes in the heart structure and function through the induction of inflammation and fibrosis, vascular remodelling, hypertrophy, and some others. This review aims to explain the basic mechanisms behind cardiac remodelling following cancer therapy by different anti-cancer modalities.
摘要:
心脏重塑的特征是功能和形态特性的异常变化,如直径,质量,空腔的正常直径,心形,纤维化,血管和心层增厚,心肌病,炎症细胞浸润,还有其他一些。这些损害与收缩和舒张异常的损害有关,对心室功能的损害,和血管重塑,这可能会导致心力衰竭和死亡。心脏暴露于辐射或抗癌药物,包括化疗药物,如阿霉素,受体酪氨酸激酶抑制剂(RTKIs),如伊马替尼,和免疫检查点抑制剂(ICIs)可以通过诱导炎症和纤维化诱导心脏结构和功能的几种异常变化,血管重塑,肥大,还有其他一些。这篇综述旨在解释通过不同的抗癌方式进行癌症治疗后心脏重塑的基本机制。