Abstract：
Dermatologic medications have been linked to issues with safety during pregnancy and lactation. Despite this, limited research, often with conflicting findings, has been published on the association between dermatologic medications, male infertility, sexual dysfunction and teratogenicity following paternal exposure.
This review seeks to provide evidence-based guidance for physicians who are prescribing dermatologic medications to male patients who are trying to conceive.
Common medications used in the largest outpatient specialist dermatologic centre in Singapore were the focus of this review. A PubMed search using MeSH terms from inception to April 22, 2021, was conducted. A secondary search was conducted to include common non-dermatologic medications. Drug information from various online clinical resources and the Tenth Edition of Drugs in Pregnancy and Lactation was also used as a reference.
In this review of 234 studies, 131 medications were covered. A total of 34 medications were associated with male infertility and sexual dysfunction, while 16 medications were implicated with concerns of teratogenicity.
Physicians are advised to discuss the potential impact on male fertility and teratogenicity with males who are trying to conceive while taking into consideration the clinical efficacy and tolerability of these medications and alternative treatments.
This review seeks to provide evidence-based guidance for physicians who are prescribing dermatologic medications to male patients who are trying to conceive.
Common medications used in the largest outpatient specialist dermatologic centre in Singapore were the focus of this review. A PubMed search using MeSH terms from inception to April 22, 2021, was conducted. A secondary search was conducted to include common non-dermatologic medications. Drug information from various online clinical resources and the Tenth Edition of Drugs in Pregnancy and Lactation was also used as a reference.
In this review of 234 studies, 131 medications were covered. A total of 34 medications were associated with male infertility and sexual dysfunction, while 16 medications were implicated with concerns of teratogenicity.
Physicians are advised to discuss the potential impact on male fertility and teratogenicity with males who are trying to conceive while taking into consideration the clinical efficacy and tolerability of these medications and alternative treatments.
摘要：
皮肤科药物与怀孕和哺乳期间的安全问题有关。尽管如此,有限的研究，经常有相互矛盾的发现，已经发表了皮肤科药物之间的关联，男性不育,父亲暴露后的性功能障碍和致畸性。
这篇综述旨在为试图怀孕的男性患者开皮肤科药物的医生提供循证指导。
本综述的重点是新加坡最大的门诊专科皮肤病中心使用的常用药物。从开始到2021年4月22日，使用MeSH术语进行了PubMed搜索。进行了二次搜索，以包括常见的非皮肤病药物。来自各种在线临床资源和第十版《妊娠和哺乳期药物》的药物信息也被用作参考。
在这篇对234项研究的综述中，131种药物被覆盖。共有34种药物与男性不育和性功能障碍有关，而16种药物与致畸性的担忧有关。
建议医生与试图受孕的男性讨论对男性生育力和致畸性的潜在影响，同时考虑这些药物和替代疗法的临床疗效和耐受性。
这篇综述旨在为试图怀孕的男性患者开皮肤科药物的医生提供循证指导。
本综述的重点是新加坡最大的门诊专科皮肤病中心使用的常用药物。从开始到2021年4月22日，使用MeSH术语进行了PubMed搜索。进行了二次搜索，以包括常见的非皮肤病药物。来自各种在线临床资源和第十版《妊娠和哺乳期药物》的药物信息也被用作参考。
在这篇对234项研究的综述中，131种药物被覆盖。共有34种药物与男性不育和性功能障碍有关，而16种药物与致畸性的担忧有关。
建议医生与试图受孕的男性讨论对男性生育力和致畸性的潜在影响，同时考虑这些药物和替代疗法的临床疗效和耐受性。
