PDF(Pubmed)
Abstract：
UNASSIGNED: Gait impairment is a debilitating and progressive feature of Parkinson\'s disease (PD). Increasing evidence suggests that gait control is partly mediated by cholinergic signaling from the pedunculopontine nucleus (PPN).
UNASSIGNED: We investigated whether PPN structural connectivity correlated with quantitative gait measures in PD.
UNASSIGNED: Twenty PD patients and 15 controls underwent diffusion tensor imaging to quantify structural connectivity of the PPN. Whole brain analysis using tract-based spatial statistics and probabilistic tractography were performed using the PPN as a seed region of interest for cortical and subcortical target structures. Gait metrics were recorded in subjects\' medication ON and OFF states, and were used to determine if specific features of gait dysfunction in PD were related to PPN structural connectivity.
UNASSIGNED: Tract-based spatial statistics revealed reduced structural connectivity involving the corpus callosum and right superior corona radiata, but did not correlate with gait measures. Abnormalities in PPN structural connectivity in PD were lateralized to the right hemisphere, with pathways involving the right caudate nucleus, amygdala, pre-supplementary motor area, and primary somatosensory cortex. Altered connectivity of the right PPN-caudate nucleus was associated with worsened cadence, stride time, and velocity while in the ON state; altered connectivity of the right PPN-amygdala was associated with reduced stride length in the OFF state.
UNASSIGNED: Our exploratory analysis detects a potential correlation between gait dysfunction in PD and a characteristic pattern of connectivity deficits in the PPN network involving the right caudate nucleus and amygdala, which may be investigated in future larger studies.
UNASSIGNED: We investigated whether PPN structural connectivity correlated with quantitative gait measures in PD.
UNASSIGNED: Twenty PD patients and 15 controls underwent diffusion tensor imaging to quantify structural connectivity of the PPN. Whole brain analysis using tract-based spatial statistics and probabilistic tractography were performed using the PPN as a seed region of interest for cortical and subcortical target structures. Gait metrics were recorded in subjects\' medication ON and OFF states, and were used to determine if specific features of gait dysfunction in PD were related to PPN structural connectivity.
UNASSIGNED: Tract-based spatial statistics revealed reduced structural connectivity involving the corpus callosum and right superior corona radiata, but did not correlate with gait measures. Abnormalities in PPN structural connectivity in PD were lateralized to the right hemisphere, with pathways involving the right caudate nucleus, amygdala, pre-supplementary motor area, and primary somatosensory cortex. Altered connectivity of the right PPN-caudate nucleus was associated with worsened cadence, stride time, and velocity while in the ON state; altered connectivity of the right PPN-amygdala was associated with reduced stride length in the OFF state.
UNASSIGNED: Our exploratory analysis detects a potential correlation between gait dysfunction in PD and a characteristic pattern of connectivity deficits in the PPN network involving the right caudate nucleus and amygdala, which may be investigated in future larger studies.
摘要：
■步态障碍是帕金森病（PD）的一个衰弱和进行性特征。越来越多的证据表明，步态控制部分是由来自脚尖桥脑核（PPN）的胆碱能信号介导的。
■我们调查了在PD中PPN结构连通性是否与定量步态测量相关。
■20例PD患者和15例对照者接受扩散张量成像以量化PPN的结构连通性。使用PPN作为皮质和皮质下目标结构的感兴趣种子区域,使用基于道的空间统计和概率纤维束成像进行全脑分析。步态指标记录在受试者的药物开启和关闭状态，并用于确定PD中步态功能障碍的特定特征是否与PPN结构连接有关。
■基于区域的空间统计数据显示，涉及call体和右上冠状辐射体的结构连通性降低，但与步态测量无关。PD中PPN结构连通性异常位于右半球，路径涉及右尾状核，杏仁核,预补充电机区域，和初级体感皮层。右PPN尾状核的连通性改变与节奏恶化有关，跨步时间,处于ON状态时的速度和速度；右PPN-杏仁核的连通性改变与OFF状态下的步幅减少有关。
■我们的探索性分析检测到PD中的步态功能障碍与涉及右尾状核和杏仁核的PPN网络中连通性缺陷的特征模式之间的潜在相关性，这可能会在未来更大的研究中进行调查。
■我们调查了在PD中PPN结构连通性是否与定量步态测量相关。
■20例PD患者和15例对照者接受扩散张量成像以量化PPN的结构连通性。使用PPN作为皮质和皮质下目标结构的感兴趣种子区域,使用基于道的空间统计和概率纤维束成像进行全脑分析。步态指标记录在受试者的药物开启和关闭状态，并用于确定PD中步态功能障碍的特定特征是否与PPN结构连接有关。
■基于区域的空间统计数据显示，涉及call体和右上冠状辐射体的结构连通性降低，但与步态测量无关。PD中PPN结构连通性异常位于右半球，路径涉及右尾状核，杏仁核,预补充电机区域，和初级体感皮层。右PPN尾状核的连通性改变与节奏恶化有关，跨步时间,处于ON状态时的速度和速度；右PPN-杏仁核的连通性改变与OFF状态下的步幅减少有关。
■我们的探索性分析检测到PD中的步态功能障碍与涉及右尾状核和杏仁核的PPN网络中连通性缺陷的特征模式之间的潜在相关性，这可能会在未来更大的研究中进行调查。
