PDF(Pubmed)
Abstract：
Metabolic syndrome in humans is commonly associated with cardiovascular dysfunction, including atrial fibrillation and left ventricular diastolic dysfunction. Although many differences exist between human and equine metabolic syndrome, both of these conditions share some degree of insulin resistance. The aims of this pilot study were to investigate the relationship between insulin sensitivity and cardiac function. Seven horses (five mares, two geldings, aged 17.2 ± 4.2 years, weight 524 ± 73 kg) underwent insulin-modified frequently sampled intravenous glucose tolerance testing to determine insulin sensitivity (mean 2.21 ± 0.03 × 10-4 L/min/mU). Standard echocardiograms were performed on each horse, including two-dimensional, M-mode, and pulse-wave tissue Doppler imaging. Pearson and Spearman correlation analyses were used to determine the association of insulin sensitivity with echocardiographic measures of cardiac function in 5 horses. Insulin sensitivity was found to be significantly correlated with peak myocardial velocity during late diastole (r = 0.89, P = 0.0419), ratio between peak myocardial velocity in early and late diastole (r = -0.92, P = 0.0263), isovolumetric relaxation time (r = -0.97, P = 0.0072), and isovolumetric contraction time (ρ = -0.90, P = 0.0374). These preliminary data suggest that decreased insulin sensitivity is correlated with alterations in both systolic and diastolic function, as measured with tissue Doppler imaging (TDI). Due to the small sample size of this study, the relationship between insulin sensitivity and myocardial function in horses requires further investigation.
摘要：
人类代谢综合征通常与心血管功能障碍有关，包括心房颤动和左心室舒张功能不全。尽管人类和马代谢综合征之间存在许多差异，这两种疾病都有一定程度的胰岛素抵抗.这项初步研究的目的是研究胰岛素敏感性与心功能之间的关系。七匹马（五匹母马，两个凝胶，年龄17.2±4.2岁，体重524±73kg）接受了胰岛素改良的频繁采样的静脉葡萄糖耐量测试，以确定胰岛素敏感性（平均2.21±0.03×10-4L/min/mU）。对每一匹马进行标准超声心动图检查，包括二维，M模式,和脉搏波组织多普勒成像。Pearson和Spearman相关性分析用于确定5匹马的胰岛素敏感性与心脏功能的超声心动图测量值的相关性。发现胰岛素敏感性与舒张后期的峰值心肌速度显着相关（r=0.89，P=0.0419）。心肌舒张早期和晚期峰值速度的比值(r=-0.92,P=0.0263),等体积弛豫时间（r=-0.97，P=0.0072），和等容收缩时间(ρ=-0.90，P=0.0374)。这些初步数据表明，胰岛素敏感性降低与收缩和舒张功能的改变有关。用组织多普勒成像（TDI）测量。由于本研究的样本量小，胰岛素敏感性与马心肌功能之间的关系需要进一步研究.
