PDF(Pubmed)
Abstract：
UNASSIGNED: City living might lead to a higher risk of psychiatric disease, but to date there is no evidence of any correlation between an urban environment and the occurrence of neural autoantibodies in psychiatric disease. Our aim is to identify whether the number of patients with and without neural autoantibodies living in diverse rural and urban environments differ.
UNASSIGNED: We enrolled retrospectively a cohort of 167 psychiatric patients via a cross-sectional design from the Department of Psychiatry and Psychotherapy University Medical Center Göttingen and determined serum and/or CSF neural autoantibodies in them. The patients live in the German states of Lower Saxony, Thuringia, and Hessen. Their data were investigated in conjunction with the location of their primary residence. We categorized them into five different categories depending upon their primary residence: one rural and four different urban environments depending on their population numbers.
UNASSIGNED: We identified 36 psychiatric patients with neural autoantibodies, and 131 psychiatric patients with none. In total, 24 psychiatric patients with neural autoantibodies were classified as sharing a possible, probable, or definitive autoimmune origin according to our recently set criteria. We observed as a non-significant trend that more psychiatric patients with neural autoantibodies and a probable or definitive autoimmune origin (45.8%) live in a major city with over 100,000 inhabitants than do psychiatric patients presenting no evidence of autoantibodies (26.4%). However, we identified no relevant differences between (1) psychiatric patients with and without neural autoantibodies or between (2) psychiatric patients with a possible, probable, or definitive autoimmune origin and those without such autoantibodies in relation to the diverse rural and urban environmental settings.
UNASSIGNED: The inherently different aspects of rural and urban environments do not appear to be relevant in determining the frequency of neural autoantibodies in psychiatric patients in Lower Saxony, Thuringia, and Hessen in Germany. Furthermore, large-scale studies involving other states across Germany should be conducted to exclude any regional differences and to examine the tendency of a higher frequency in large cities of autoimmune-mediated psychiatric syndromes.
UNASSIGNED: We enrolled retrospectively a cohort of 167 psychiatric patients via a cross-sectional design from the Department of Psychiatry and Psychotherapy University Medical Center Göttingen and determined serum and/or CSF neural autoantibodies in them. The patients live in the German states of Lower Saxony, Thuringia, and Hessen. Their data were investigated in conjunction with the location of their primary residence. We categorized them into five different categories depending upon their primary residence: one rural and four different urban environments depending on their population numbers.
UNASSIGNED: We identified 36 psychiatric patients with neural autoantibodies, and 131 psychiatric patients with none. In total, 24 psychiatric patients with neural autoantibodies were classified as sharing a possible, probable, or definitive autoimmune origin according to our recently set criteria. We observed as a non-significant trend that more psychiatric patients with neural autoantibodies and a probable or definitive autoimmune origin (45.8%) live in a major city with over 100,000 inhabitants than do psychiatric patients presenting no evidence of autoantibodies (26.4%). However, we identified no relevant differences between (1) psychiatric patients with and without neural autoantibodies or between (2) psychiatric patients with a possible, probable, or definitive autoimmune origin and those without such autoantibodies in relation to the diverse rural and urban environmental settings.
UNASSIGNED: The inherently different aspects of rural and urban environments do not appear to be relevant in determining the frequency of neural autoantibodies in psychiatric patients in Lower Saxony, Thuringia, and Hessen in Germany. Furthermore, large-scale studies involving other states across Germany should be conducted to exclude any regional differences and to examine the tendency of a higher frequency in large cities of autoimmune-mediated psychiatric syndromes.
摘要：
■城市生活可能导致患精神疾病的风险更高，但是迄今为止，没有证据表明城市环境与精神疾病中神经自身抗体的发生之间存在任何相关性。我们的目标是确定生活在不同的农村和城市环境中的有和没有神经自身抗体的患者数量是否不同。
■我们通过横断面设计从哥廷根精神病学和心理治疗大学医学中心招募了167名精神病患者，并测定了他们的血清和/或CSF神经自身抗体。病人住在德国下萨克森州,图林根,还有Hessen.他们的数据是结合他们的主要居住地进行调查的。根据他们的主要居住地，我们将他们分为五个不同的类别：一个农村环境和四个不同的城市环境，这取决于他们的人口数量。
■我们确定了36名患有神经自身抗体的精神病患者，和131名精神病患者没有。总的来说,24名患有神经自身抗体的精神病患者被归类为共享可能，可能,或者根据我们最近设定的标准确定的自身免疫起源。我们观察到一个不显着的趋势，即有神经自身抗体和可能或确定的自身免疫起源的精神病患者（45.8％）生活在人口超过100,000的主要城市中，而没有出现自身抗体证据的精神病患者（26.4％）。然而,我们发现（1）有和没有神经自身抗体的精神病患者之间或（2）精神病患者之间没有相关差异，可能,或确定的自身免疫起源，以及与不同的农村和城市环境相关的没有这种自身抗体的人。
■农村和城市环境固有的不同方面似乎与确定下萨克森州精神病患者中神经自身抗体的发生频率无关，图林根,和德国的黑森州。此外，应进行涉及德国其他州的大规模研究,以排除任何地区差异,并研究大城市自身免疫介导的精神病综合征发生频率较高的趋势.
■我们通过横断面设计从哥廷根精神病学和心理治疗大学医学中心招募了167名精神病患者，并测定了他们的血清和/或CSF神经自身抗体。病人住在德国下萨克森州,图林根,还有Hessen.他们的数据是结合他们的主要居住地进行调查的。根据他们的主要居住地，我们将他们分为五个不同的类别：一个农村环境和四个不同的城市环境，这取决于他们的人口数量。
■我们确定了36名患有神经自身抗体的精神病患者，和131名精神病患者没有。总的来说,24名患有神经自身抗体的精神病患者被归类为共享可能，可能,或者根据我们最近设定的标准确定的自身免疫起源。我们观察到一个不显着的趋势，即有神经自身抗体和可能或确定的自身免疫起源的精神病患者（45.8％）生活在人口超过100,000的主要城市中，而没有出现自身抗体证据的精神病患者（26.4％）。然而,我们发现（1）有和没有神经自身抗体的精神病患者之间或（2）精神病患者之间没有相关差异，可能,或确定的自身免疫起源，以及与不同的农村和城市环境相关的没有这种自身抗体的人。
■农村和城市环境固有的不同方面似乎与确定下萨克森州精神病患者中神经自身抗体的发生频率无关，图林根,和德国的黑森州。此外，应进行涉及德国其他州的大规模研究,以排除任何地区差异,并研究大城市自身免疫介导的精神病综合征发生频率较高的趋势.
