PDF(Pubmed)
Abstract：
UNASSIGNED: To assess air pollution-induced changes on ocular surface and tear cytokine levels.
UNASSIGNED: As a prospective multicenter cohort study, 387 dry eye disease (DED) participants were recruited from five provinces in China and underwent measurements of ocular surface disease index (OSDI), Schirmer\'s I test (ST), tear meniscus height (TMH), tear film break-up time (TBUT), corneal fluorescein staining (CFS), meibomian gland (MG) function, and tear cytokines. The associations between ocular surface parameters and exposure to particulate matter (PM), ozone (O3), nitrogen dioxide (NO2), and sulfur dioxide (SO2) for 1 day, 1 week, and 1 month before the examination were analyzed in single- and multi-pollutant models adjusted for confounding factors.
UNASSIGNED: In the multi-pollutant model, the OSDI score was positively correlated with PM with diameter ≤2.5 μm (PM2.5), O3, and SO2 exposure [PM2.5: β (1 week/month) = 0.229 (95% confidence interval (CI): 0.035-0.424)/0.211 (95% CI: 0.160-0.583); O3: β (1 day/week/month) = 0.403 (95% CI: 0.229-0.523)/0.471 (95% CI: 0.252-0.693)/0.468 (95% CI: 0.215-0.732); SO2: β (1 day/week) = 0.437 (95% CI: 0.193-0.680)/0.470 (95% CI: 0.040-0.901)]. Tear secretion was negatively correlated with O3 and NO2 exposures but positively correlated with PM2.5 levels. Air pollutants were negatively correlated with TBUT and positively related with CFS score. Besides SO2, all other pollutants were associated with aggravated MG dysfunction (MG expression, secretion, and loss) and tear cytokines increasement, such as PM2.5 and interleukin-8 (IL-8) [β (1 day) = 0.016 (95% CI: 0.003-0.029)], PM with diameter ≤10 μm (PM10) and IL-6 [β (1 day) = 0.019 (95% CI: 0.006-0.033)], NO2 and IL-6 [β (1 month) = 0.045 (95% CI: 0.018-0.072)], among others. The effects of air pollutants on DED symptoms/signs, MG functions and tear cytokines peaked within 1 week, 1 month, and 1 day, respectively.
UNASSIGNED: Increased PM2.5, O3, and SO2 exposures caused ocular discomfort and damage with tear film instability. PM10 exposure led to tear film instability and ocular injury. PM, O3, and NO2 exposures aggravated MG dysfunction and upregulated tear cytokine levels. Therefore, each air pollutant may influence DED via different mechanisms within different time windows.
UNASSIGNED: As a prospective multicenter cohort study, 387 dry eye disease (DED) participants were recruited from five provinces in China and underwent measurements of ocular surface disease index (OSDI), Schirmer\'s I test (ST), tear meniscus height (TMH), tear film break-up time (TBUT), corneal fluorescein staining (CFS), meibomian gland (MG) function, and tear cytokines. The associations between ocular surface parameters and exposure to particulate matter (PM), ozone (O3), nitrogen dioxide (NO2), and sulfur dioxide (SO2) for 1 day, 1 week, and 1 month before the examination were analyzed in single- and multi-pollutant models adjusted for confounding factors.
UNASSIGNED: In the multi-pollutant model, the OSDI score was positively correlated with PM with diameter ≤2.5 μm (PM2.5), O3, and SO2 exposure [PM2.5: β (1 week/month) = 0.229 (95% confidence interval (CI): 0.035-0.424)/0.211 (95% CI: 0.160-0.583); O3: β (1 day/week/month) = 0.403 (95% CI: 0.229-0.523)/0.471 (95% CI: 0.252-0.693)/0.468 (95% CI: 0.215-0.732); SO2: β (1 day/week) = 0.437 (95% CI: 0.193-0.680)/0.470 (95% CI: 0.040-0.901)]. Tear secretion was negatively correlated with O3 and NO2 exposures but positively correlated with PM2.5 levels. Air pollutants were negatively correlated with TBUT and positively related with CFS score. Besides SO2, all other pollutants were associated with aggravated MG dysfunction (MG expression, secretion, and loss) and tear cytokines increasement, such as PM2.5 and interleukin-8 (IL-8) [β (1 day) = 0.016 (95% CI: 0.003-0.029)], PM with diameter ≤10 μm (PM10) and IL-6 [β (1 day) = 0.019 (95% CI: 0.006-0.033)], NO2 and IL-6 [β (1 month) = 0.045 (95% CI: 0.018-0.072)], among others. The effects of air pollutants on DED symptoms/signs, MG functions and tear cytokines peaked within 1 week, 1 month, and 1 day, respectively.
UNASSIGNED: Increased PM2.5, O3, and SO2 exposures caused ocular discomfort and damage with tear film instability. PM10 exposure led to tear film instability and ocular injury. PM, O3, and NO2 exposures aggravated MG dysfunction and upregulated tear cytokine levels. Therefore, each air pollutant may influence DED via different mechanisms within different time windows.
摘要：
■评估空气污染引起的眼表和泪液细胞因子水平的变化。
■作为一项前瞻性多中心队列研究，从中国五个省份招募了387名干眼症（DED）参与者，并进行了眼表疾病指数（OSDI）的测量，Schirmer\'sItest(ST),撕裂弯月面高度（TMH），泪膜破裂时间（TBUT），角膜荧光素染色（CFS），睑板腺（MG）功能，和撕裂细胞因子。眼表参数与暴露于颗粒物（PM）之间的关联，臭氧(O3)二氧化氮(NO2),和二氧化硫（SO2）1天，1周,和检查前1个月，在单污染物和多污染物模型中分析了混杂因素。
■在多污染物模型中，OSDI评分与直径≤2.5μm（PM2.5）的PM呈正相关，O3，和SO2暴露[PM2.5：β（1周/月）=0.229（95％置信区间（CI）：0.035-0.424）/0.211（95％CI：0.160-0.583）；O3：β（1天/周/月）=0.403（95％CI：0.229-0.523）/0.471（95％CI：0.252-0.693）/0.468（95％CI：0.泪液分泌与O3和NO2暴露呈负相关，但与PM2.5水平呈正相关。大气污染物与TBUT呈负相关,与CFS评分呈正相关。除SO2外，所有其他污染物均与加重的MG功能障碍有关(MG表达，分泌，和损失)和撕裂细胞因子增加，例如PM2.5和白细胞介素-8（IL-8）[β（1天）=0.016（95％CI：0.003-0.029）]，直径≤10μm的PM（PM10）和IL-6[β（1天）=0.019（95％CI：0.006-0.033）]，NO2和IL-6[β（1个月）=0.045（95％CI：0.018-0.072）]，在其他人中。空气污染物对DED症状/体征的影响，MG功能和泪液细胞因子在1周内达到峰值，1个月,1天,分别。
■增加的PM2.5，O3和SO2暴露导致眼部不适和泪膜不稳定的损害。PM10暴露导致泪膜不稳定和眼外伤。PM,O3和NO2暴露会加重MG功能障碍并上调泪液细胞因子水平。因此,每种空气污染物都可能在不同的时间窗口内通过不同的机制影响DED。
■作为一项前瞻性多中心队列研究，从中国五个省份招募了387名干眼症（DED）参与者，并进行了眼表疾病指数（OSDI）的测量，Schirmer\'sItest(ST),撕裂弯月面高度（TMH），泪膜破裂时间（TBUT），角膜荧光素染色（CFS），睑板腺（MG）功能，和撕裂细胞因子。眼表参数与暴露于颗粒物（PM）之间的关联，臭氧(O3)二氧化氮(NO2),和二氧化硫（SO2）1天，1周,和检查前1个月，在单污染物和多污染物模型中分析了混杂因素。
■在多污染物模型中，OSDI评分与直径≤2.5μm（PM2.5）的PM呈正相关，O3，和SO2暴露[PM2.5：β（1周/月）=0.229（95％置信区间（CI）：0.035-0.424）/0.211（95％CI：0.160-0.583）；O3：β（1天/周/月）=0.403（95％CI：0.229-0.523）/0.471（95％CI：0.252-0.693）/0.468（95％CI：0.泪液分泌与O3和NO2暴露呈负相关，但与PM2.5水平呈正相关。大气污染物与TBUT呈负相关,与CFS评分呈正相关。除SO2外，所有其他污染物均与加重的MG功能障碍有关(MG表达，分泌，和损失)和撕裂细胞因子增加，例如PM2.5和白细胞介素-8（IL-8）[β（1天）=0.016（95％CI：0.003-0.029）]，直径≤10μm的PM（PM10）和IL-6[β（1天）=0.019（95％CI：0.006-0.033）]，NO2和IL-6[β（1个月）=0.045（95％CI：0.018-0.072）]，在其他人中。空气污染物对DED症状/体征的影响，MG功能和泪液细胞因子在1周内达到峰值，1个月,1天,分别。
■增加的PM2.5，O3和SO2暴露导致眼部不适和泪膜不稳定的损害。PM10暴露导致泪膜不稳定和眼外伤。PM,O3和NO2暴露会加重MG功能障碍并上调泪液细胞因子水平。因此,每种空气污染物都可能在不同的时间窗口内通过不同的机制影响DED。
