PDF(Pubmed)
Abstract：
Retinoblastoma (RB) is one of the most common childhood cancers caused by RB gene mutations (tumor suppressor gene in various patients). A better understanding of molecular pathways and the development of new diagnostic approaches may lead to better treatment for RB patients. The number of studies on ceRNA axes is increasing, emphasizing the significance of these axes in RB. Circular RNAs (circRNAs) play a vital role in competing endogenous RNA (ceRNA) regulatory axes by sponging microRNAs and regulating gene expression. Because of the broadness of ceRNA interaction networks, they may assist in investigating treatment targets in RB. This study conducted a systematic scoping review to evaluate verified loops of ceRNA in RB, focusing on the ceRNA axis and its relationship to circRNAs. This scoping review was carried out using a six-step strategy and the Prisma guideline, and it involved systematically searching the publications of seven databases. Out of 363 records, sixteen articles were entirely consistent with the defined inclusion criteria and were summarized in the relevant table. The majority of the studies focused on the circRNAs circ_0000527, circ_0000034, and circTET1, with approximately two-fifths of the studies focusing on a single circRNA. Understanding the many features of this regulatory structure may help elucidate RB\'s unknown causative factors and provide novel molecular potential therapeutic targets and medical fields.
摘要：
视网膜母细胞瘤（RB）是由RB基因突变（各种患者的抑癌基因）引起的最常见的儿童癌症之一。对分子途径的更好理解和新诊断方法的发展可能会导致更好的治疗RB患者。关于ceRNA轴的研究越来越多，强调这些轴在RB中的重要性。环状RNA（circularRNAs，circRNAs）通过形成microRNAs和调节基因表达，在竞争内源性RNA（ceRNA）调节轴中起着至关重要的作用。由于ceRNA相互作用网络的广泛性，他们可能有助于研究RB的治疗目标。本研究进行了系统的范围审查，以评估RB中已验证的ceRNA环，专注于ceRNA轴及其与circRNAs的关系。这项范围审查是使用六步策略和Prisma指南进行的，它涉及系统地搜索七个数据库的出版物。在363条记录中,16篇文章与定义的纳入标准完全一致,并在相关表格中进行了总结.大多数研究集中在circRNAcirc_0000527，circ_0000034和circTET1，大约五分之二的研究集中在单个circRNA上。了解这种调节结构的许多特征可能有助于阐明RB的未知致病因素，并提供新的分子潜在治疗靶标和医学领域。
