Abstract：
The growth of 14 Aspergillus strains belonging to nine species was studied under combinatorial deferriprone - H2O2 (iron-chelation - oxidative) stress. When deferriprone pretreated mycelia were subjected to even a weak oxidative stress, the growth inhibitory effect of iron-chelation stress was enhanced in 10 out of 14 strains. In contrast, oxidative stress pretreatment of conidia increased their deferriprone tolerance in 10 strains. Applying iron-chelators as antifungal agent or adjuvant can enhance the efficiency of the combinatorial iron withdrawal - oxidative stress strategy of our immune system and may reduce the survival of conidia escaped from the oxidative attack of pulmonary macrophages.
摘要：
在组合去铁蛋白-H2O2（铁螯合-氧化）胁迫下研究了属于9种的14种曲霉菌株的生长。当去铁酮预处理的菌丝体受到甚至弱的氧化应激时，14个菌株中有10个增强了铁螯合胁迫的生长抑制作用。相比之下,分生孢子的氧化应激预处理增加了10个菌株的去铁剂耐受性。使用铁螯合剂作为抗真菌剂或佐剂可以提高免疫系统的联合铁戒断-氧化应激策略的效率，并可能减少从肺巨噬细胞的氧化攻击中逃脱的分生孢子的存活。
