PDF(Pubmed)
Abstract：
UNASSIGNED: and importance: Infertility affects approximately 10-15% of couples worldwide. Several causes are incriminated such as hormonal abnormalities, infections, genetic disorders, testicular cancer, varicocele, and others. Herein, we report a case of an unusual association between testicular tuberculosis and microdeletion of the Y chromosome in an infertile patient and we discuss the diagnostic and therapeutic difficulties.
UNASSIGNED: A 36-year-old patient, a smoker, with no previous history consulted our department for primary infertility for 2 years. The clinical examination was normal. The sperm count showed azoospermia. karyotype analysis confirmed the diagnosis of a microdeletion of the Y chromosome. A testicular biopsy was performed. The microscopic analysis did not find any sperm cells. However, the histopathological examination was in favor of testicular TB. The patient received 6 months of anti-TB treatment. He remained azoospermic.
UNASSIGNED: Azoospermia is defined as the absence of sperm in the ejaculate in two different samples. This condition is classified as obstructive and non-obstructive. The etiology of this condition is either an intrinsic testicular deficiency or an insufficient production of gonadotropins. Genetic and chromosomal abnormalities should be investigated due to the higher incidence in azoospermic patients compared to the normal population. Testicular causes are dominated by infections, trauma, ischemia, and iatrogenic causes such as chemotherapy and radiotherapy. Genetic causes are dominated by Klinefelter syndrome and Y-chromosome microdeletions.
UNASSIGNED: Azoospermia is a frequent cause of male infertility. Several causes are incriminated such as hormonal abnormalities, infections, genetic disorders, and others. In some cases, this condition can be multifactorial.
UNASSIGNED: A 36-year-old patient, a smoker, with no previous history consulted our department for primary infertility for 2 years. The clinical examination was normal. The sperm count showed azoospermia. karyotype analysis confirmed the diagnosis of a microdeletion of the Y chromosome. A testicular biopsy was performed. The microscopic analysis did not find any sperm cells. However, the histopathological examination was in favor of testicular TB. The patient received 6 months of anti-TB treatment. He remained azoospermic.
UNASSIGNED: Azoospermia is defined as the absence of sperm in the ejaculate in two different samples. This condition is classified as obstructive and non-obstructive. The etiology of this condition is either an intrinsic testicular deficiency or an insufficient production of gonadotropins. Genetic and chromosomal abnormalities should be investigated due to the higher incidence in azoospermic patients compared to the normal population. Testicular causes are dominated by infections, trauma, ischemia, and iatrogenic causes such as chemotherapy and radiotherapy. Genetic causes are dominated by Klinefelter syndrome and Y-chromosome microdeletions.
UNASSIGNED: Azoospermia is a frequent cause of male infertility. Several causes are incriminated such as hormonal abnormalities, infections, genetic disorders, and others. In some cases, this condition can be multifactorial.
摘要：
■和重要性：全世界约有10-15%的夫妇受不孕症影响。有几个原因是有罪的，如荷尔蒙异常，感染,遗传性疾病,睾丸癌,精索静脉曲张,和其他人。在这里，我们报道了一例不育患者睾丸结核与Y染色体微缺失之间异常关联的病例,并讨论了诊断和治疗困难.
■一位36岁的病人,一个吸烟者,在没有既往病史的情况下，因原发性不孕症咨询了我们部门2年。临床检查正常。精子计数显示无精子症。核型分析证实了Y染色体微缺失的诊断。进行睾丸活检。显微镜分析没有发现任何精子细胞。然而,组织病理学检查有利于睾丸结核。患者接受了6个月的抗结核治疗。他仍然是无精子症。
■无精子症定义为两个不同样品的射精中没有精子。这种情况分为阻塞性和非阻塞性。这种情况的病因是内在的睾丸缺陷或促性腺激素产生不足。由于无精子症患者的发病率高于正常人群，因此应调查遗传和染色体异常。睾丸的原因主要是感染，创伤,缺血,和医源性原因，如化疗和放疗。遗传原因主要是Klinefelter综合征和Y染色体微缺失。
■无精子症是男性不育的常见原因。有几个原因是有罪的，如荷尔蒙异常，感染,遗传性疾病,和其他人。在某些情况下,这种情况可以是多因素的。
■一位36岁的病人,一个吸烟者,在没有既往病史的情况下，因原发性不孕症咨询了我们部门2年。临床检查正常。精子计数显示无精子症。核型分析证实了Y染色体微缺失的诊断。进行睾丸活检。显微镜分析没有发现任何精子细胞。然而,组织病理学检查有利于睾丸结核。患者接受了6个月的抗结核治疗。他仍然是无精子症。
■无精子症定义为两个不同样品的射精中没有精子。这种情况分为阻塞性和非阻塞性。这种情况的病因是内在的睾丸缺陷或促性腺激素产生不足。由于无精子症患者的发病率高于正常人群，因此应调查遗传和染色体异常。睾丸的原因主要是感染，创伤,缺血,和医源性原因，如化疗和放疗。遗传原因主要是Klinefelter综合征和Y染色体微缺失。
■无精子症是男性不育的常见原因。有几个原因是有罪的，如荷尔蒙异常，感染,遗传性疾病,和其他人。在某些情况下,这种情况可以是多因素的。
