Abstract：
Severe fever with thrombocytopenia syndrome (SFTS) has been acknowledged as an emerging infectious disease that is caused by the SFTS virus (SFTSV). The main clinical features of SFTS on presentation include fever, thrombocytopenia, leukocytopenia and gastrointestinal symptoms. The mortality rate is estimated to range between 5‑30% in East Asia. However, SFTSV infection is increasing on an annual basis globally and is becoming a public health problem. The transmission cycle of SFTSV remains poorly understood, which is compounded by the pathogenesis of SFTS not being fully elucidated. Since the mechanism underlying the host immune response towards SFTSV is also unclear, there are no effective vaccines or specific therapeutic agents against SFTS, with supportive care being the only realistic option. Therefore, it is now crucial to understand all aspects of the host‑virus interaction following SFTSV infection, including the antiviral states and viral evasion mechanisms. In the present review, recent research progress into the possible host immune responses against SFTSV was summarized, which may be useful in designing novel therapeutics against SFTS.
摘要：
严重发热伴血小板减少综合征（SFTS）已被认为是由SFTS病毒（SFTSV）引起的新兴传染病。SFTS的主要临床特征包括发热，血小板减少症,白细胞减少和胃肠道症状。据估计，东亚的死亡率在5-30%之间。然而,SFTSV感染在全球范围内每年都在增加，并且正在成为一个公共卫生问题。SFTSV的传输周期仍然知之甚少，SFTS的发病机制尚未完全阐明。由于宿主对SFTSV免疫应答的潜在机制也不清楚，没有针对SFTS的有效疫苗或特异性治疗剂，支持性护理是唯一现实的选择。因此,现在，了解SFTSV感染后宿主与病毒相互作用的各个方面至关重要，包括抗病毒状态和病毒逃避机制。在本次审查中，综述了近年来针对SFTSV可能的宿主免疫应答的研究进展,可用于设计针对SFTS的新疗法。
