PDF(Pubmed)
Abstract：
BACKGROUND: The pathogenesis and endovascular treatment strategy for spontaneously thrombosed unruptured cerebral aneurysms have not yet been comprehensively described.
METHODS: The authors reported on a 78-year-old woman who had large bilateral unruptured cavernous carotid artery aneurysms that induced chronic disseminated intravascular coagulation and acquired factor XIII deficiency. The right aneurysm was symptomatic and partially thrombosed. Hemorrhagic diathesis and abnormal values of laboratory data improved after administration of recombinant human thrombomodulin followed by endovascular treatment in which three pipeline embolization devices were deployed for the right aneurysm.
CONCLUSIONS: To the best of the authors\' knowledge, this was the first report of an unruptured cerebral aneurysm leading to coagulation disorders with clinical manifestation that was treated successfully by endovascular intervention after intensive perioperative management.
METHODS: The authors reported on a 78-year-old woman who had large bilateral unruptured cavernous carotid artery aneurysms that induced chronic disseminated intravascular coagulation and acquired factor XIII deficiency. The right aneurysm was symptomatic and partially thrombosed. Hemorrhagic diathesis and abnormal values of laboratory data improved after administration of recombinant human thrombomodulin followed by endovascular treatment in which three pipeline embolization devices were deployed for the right aneurysm.
CONCLUSIONS: To the best of the authors\' knowledge, this was the first report of an unruptured cerebral aneurysm leading to coagulation disorders with clinical manifestation that was treated successfully by endovascular intervention after intensive perioperative management.
摘要：
背景：尚未全面描述自发性血栓形成的未破裂脑动脉瘤的发病机制和血管内治疗策略。
方法：作者报道了一名78岁的女性，该女性患有双侧未破裂的巨大海绵状颈动脉动脉瘤，引起慢性弥散性血管内凝血和获得性因子XIII缺乏。右侧动脉瘤有症状，部分血栓形成。在给予重组人血栓调节蛋白，然后进行血管内治疗后，出血素质和实验室数据的异常值得到改善，在血管内治疗中，为右动脉瘤部署了三个管道栓塞装置。
结论：据作者所知，这是首次报道未破裂的脑动脉瘤导致凝血障碍的临床表现,在强化围手术期治疗后通过血管内介入治疗成功.
方法：作者报道了一名78岁的女性，该女性患有双侧未破裂的巨大海绵状颈动脉动脉瘤，引起慢性弥散性血管内凝血和获得性因子XIII缺乏。右侧动脉瘤有症状，部分血栓形成。在给予重组人血栓调节蛋白，然后进行血管内治疗后，出血素质和实验室数据的异常值得到改善，在血管内治疗中，为右动脉瘤部署了三个管道栓塞装置。
结论：据作者所知，这是首次报道未破裂的脑动脉瘤导致凝血障碍的临床表现,在强化围手术期治疗后通过血管内介入治疗成功.
