Abstract：
Eosinophilic gastrointestinal disorders (EGIDs) include inflammatory conditions with enteric infiltration of eosinophils and resulting symptoms. This study aims to examine a population-based sample of patients for prevalence, mortality, and cancer risk in EGIDs distal to the esophagus.
Nationwide, population-based cohort study. EGID was identified through relevant biopsy codes from Sweden\'s all 28 pathology departments through the ESPRESSO cohort. Individuals with EGID were then matched to general population reference individuals with similar age and sex. Study participants were linked to Swedish healthcare registers. Through Cox regression, we calculated adjusted hazard ratios (aHRs) adjusting for sex, age, county, calendar period, and education.
In total, 2429 patients (56% female) were found to have EGID distal to the esophagus, representing a prevalence of about 1/4800 in the Swedish population. Mean age was 44 years with 11% children at the time of diagnosis. Mortality was increased 17% in patients with EGIDs compared to reference individuals (aHR = 1.17; 95%CI = 1.04-1.33). Excess mortality was seen in gastric and small bowel eosinophilic disease, but not colonic disease (aHR = 1.81; 95%CI = 1.32-2.48, aHR = 1.50; 95%CI = 1.18-1.89, and aHR = 0.99; 95%CI = 0.85-1.16, respectively). Cause specific mortality was driven by cancer-related death (aHR = 1.33; 95%CI = 1.05-1.69). However, this study failed to show an increase in incident cancers (aHR = 1.14; 95%CI = 0.96-1.35). Comparison of EGID individuals with their siblings yielded similar aHRs.
This study found an increased risk of death in patients with EGIDs distal to the esophagus, with cancer death driving the increase. Proximal gut disease seems to confer the greatest risk. There was no increase in incident cancers.
Nationwide, population-based cohort study. EGID was identified through relevant biopsy codes from Sweden\'s all 28 pathology departments through the ESPRESSO cohort. Individuals with EGID were then matched to general population reference individuals with similar age and sex. Study participants were linked to Swedish healthcare registers. Through Cox regression, we calculated adjusted hazard ratios (aHRs) adjusting for sex, age, county, calendar period, and education.
In total, 2429 patients (56% female) were found to have EGID distal to the esophagus, representing a prevalence of about 1/4800 in the Swedish population. Mean age was 44 years with 11% children at the time of diagnosis. Mortality was increased 17% in patients with EGIDs compared to reference individuals (aHR = 1.17; 95%CI = 1.04-1.33). Excess mortality was seen in gastric and small bowel eosinophilic disease, but not colonic disease (aHR = 1.81; 95%CI = 1.32-2.48, aHR = 1.50; 95%CI = 1.18-1.89, and aHR = 0.99; 95%CI = 0.85-1.16, respectively). Cause specific mortality was driven by cancer-related death (aHR = 1.33; 95%CI = 1.05-1.69). However, this study failed to show an increase in incident cancers (aHR = 1.14; 95%CI = 0.96-1.35). Comparison of EGID individuals with their siblings yielded similar aHRs.
This study found an increased risk of death in patients with EGIDs distal to the esophagus, with cancer death driving the increase. Proximal gut disease seems to confer the greatest risk. There was no increase in incident cancers.
摘要：
嗜酸性粒细胞性胃肠道疾病(EGID)包括具有嗜酸性粒细胞的肠浸润和所产生的症状的炎性病症。这项研究旨在检查基于人群的患者样本的患病率，死亡率,和食道远端EGIDs的癌症风险。
全国，基于人群的队列研究。通过ESPRESSO队列，通过瑞典所有28个病理科的相关活检编码鉴定EGID。然后将具有EGID的个体与具有相似年龄和性别的一般人群参考个体进行匹配。研究参与者与瑞典的医疗保健登记册相关联。通过Cox回归,我们计算了调整性别的调整后风险比(AHR)，年龄,县,日历期间,和教育。
总共，发现2429例患者（56%为女性）在食管远端有EGID，在瑞典人口中的患病率约为1/4800。平均年龄为44岁，在诊断时儿童占11％。与参考个体相比，EGIDs患者的死亡率增加了17%(aHR=1.17;95CI=1.04-1.33)。在胃和小肠嗜酸性粒细胞疾病中观察到过度死亡率，但不是结肠疾病(aHR=1.81;95CI=1.32-2.48,aHR=1.50;95CI=1.18-1.89,aHR=0.99;95CI=0.85-1.16)。原因特异性死亡率由癌症相关死亡驱动(aHR=1.33;95CI=1.05-1.69)。然而,这项研究未能显示癌症发病率增加(aHR=1.14;95CI=0.96-1.35).EGID个体与其兄弟姐妹的比较产生了相似的aHR。
这项研究发现食管远端EGIDs患者的死亡风险增加，癌症死亡推动了增长。近端肠道疾病似乎赋予最大的风险。癌症发病率没有增加。
全国，基于人群的队列研究。通过ESPRESSO队列，通过瑞典所有28个病理科的相关活检编码鉴定EGID。然后将具有EGID的个体与具有相似年龄和性别的一般人群参考个体进行匹配。研究参与者与瑞典的医疗保健登记册相关联。通过Cox回归,我们计算了调整性别的调整后风险比(AHR)，年龄,县,日历期间,和教育。
总共，发现2429例患者（56%为女性）在食管远端有EGID，在瑞典人口中的患病率约为1/4800。平均年龄为44岁，在诊断时儿童占11％。与参考个体相比，EGIDs患者的死亡率增加了17%(aHR=1.17;95CI=1.04-1.33)。在胃和小肠嗜酸性粒细胞疾病中观察到过度死亡率，但不是结肠疾病(aHR=1.81;95CI=1.32-2.48,aHR=1.50;95CI=1.18-1.89,aHR=0.99;95CI=0.85-1.16)。原因特异性死亡率由癌症相关死亡驱动(aHR=1.33;95CI=1.05-1.69)。然而,这项研究未能显示癌症发病率增加(aHR=1.14;95CI=0.96-1.35).EGID个体与其兄弟姐妹的比较产生了相似的aHR。
这项研究发现食管远端EGIDs患者的死亡风险增加，癌症死亡推动了增长。近端肠道疾病似乎赋予最大的风险。癌症发病率没有增加。
