Abstract：
UNASSIGNED: Acne is one of the most common and widespread skin conditions, affecting the health as much as patients\' quality of life. A wide variety of treatments for acne, topical and systemics, could be prescribed, depending on its degree of severity. Isotretinoin, a derivative of retinol, has been widely used for the treatment of severe forms of acne and those forms not responding to conventional treatments. In literature, there are several studies describing its efficacy, also reporting side-effects related to the drug; therefore, this has led the scientific community to request further studies qualifying its characteristics and comparing its efficacy and safety with other classic acne treatments, as well as with different treatment regimes, in order to find the dose with the best efficacy/safety ratio.
UNASSIGNED: The aim of this article is to provide a complete overview on the use of oral isotretinoin for the treatment of acne describing the efficacy, safety, and tolerability of the drug.
UNASSIGNED: Oral isotretinoin represents a valid therapeutic alternative in treating severe and mild-to-moderate acne lesions, also reducing scarring damage. There are no standardized protocols regarding the use of oral isotretinoin and its association with other therapies; however, the correct patient selection and a tailored treatment protocol according to acne lesions severity and type should be considered in order to obtain optimal results.
UNASSIGNED: The aim of this article is to provide a complete overview on the use of oral isotretinoin for the treatment of acne describing the efficacy, safety, and tolerability of the drug.
UNASSIGNED: Oral isotretinoin represents a valid therapeutic alternative in treating severe and mild-to-moderate acne lesions, also reducing scarring damage. There are no standardized protocols regarding the use of oral isotretinoin and its association with other therapies; however, the correct patient selection and a tailored treatment protocol according to acne lesions severity and type should be considered in order to obtain optimal results.
摘要：
■痤疮是最常见和最广泛的皮肤病之一，影响患者的健康和生活质量一样多。各种各样的治疗痤疮，主题和系统，可以开处方，取决于其严重程度。异维A酸,视黄醇的衍生物，已经广泛用于治疗严重形式的痤疮和那些对常规治疗没有反应的形式。在文学中,有几项研究描述了它的功效，还报告了与药物相关的副作用；因此，这导致科学界要求进一步研究鉴定其特征，并将其疗效和安全性与其他经典痤疮治疗方法进行比较，以及不同的治疗方案，以找到具有最佳疗效/安全性比的剂量。
■本文的目的是提供关于使用口服异维A酸治疗痤疮的完整概述，描述其功效，安全,和药物的耐受性。
■口服异维A酸是治疗重度和轻度至中度痤疮病变的有效治疗选择，也减少了疤痕伤害。关于口服异维甲酸的使用及其与其他疗法的关联，没有标准化的方案；然而，应根据痤疮病变的严重程度和类型考虑正确的患者选择和量身定制的治疗方案,以获得最佳结果.
■本文的目的是提供关于使用口服异维A酸治疗痤疮的完整概述，描述其功效，安全,和药物的耐受性。
■口服异维A酸是治疗重度和轻度至中度痤疮病变的有效治疗选择，也减少了疤痕伤害。关于口服异维甲酸的使用及其与其他疗法的关联，没有标准化的方案；然而，应根据痤疮病变的严重程度和类型考虑正确的患者选择和量身定制的治疗方案,以获得最佳结果.
